Actively Recruiting
Combined Kidney and Hematopoietic Stem Cell Transplantation for Tolerance Induction
Led by Rabin Medical Center · Updated on 2021-10-28
20
Participants Needed
1
Research Sites
571 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Combined transplantation of kidney and bone marrow between HLA-matched sibling donor-recipient pairs to induce immune tolerance in order to enable complete discontinuation of immunosuppressive therapy without kidney rejection. Hematopoietic stem cells are collected from the donor 4 to 8 weeks before kidney transplantation, CD34 cells are enriched by positive selection and cryopreserved. The day after kidney transplantation the recipient starts conditioning therapy with thymoglobuline, total lymphoid irradiation, steroids, tacrolimus and mycophenolate mofetil. Eleven days after kidney transplantation the stem cell graft is thawed and infused to the recipient. If mixed donor chimerism is successfully maintained more than 6 months without rejection, then immunosuppression may be tapered off until complete discontinuation.
CONDITIONS
Official Title
Combined Kidney and Hematopoietic Stem Cell Transplantation for Tolerance Induction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age older than 18 years
- Matched siblings
- No contra-indication to thymoglobuline or total lymphoid irradiation
You will not qualify if you...
- Pregnant women or breast feeding
- Infection with HIV, HBV or HCV
- Previous or presnt malignancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Rabin Medical Center
Petah Tikva, Israel, 49100
Actively Recruiting
Research Team
M
Moshe Yeshurun, MD
CONTACT
L
Liat Shargian, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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