Actively Recruiting
Combined Light, ExVivo, and Antivirals for Recipients of Lungs From HBV Donors
Led by University Health Network, Toronto · Updated on 2025-11-17
20
Participants Needed
1
Research Sites
96 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of the study is to show that transplantation of lungs from Hepatitis B-infected donors is safe when using EVLP with UV light inactivation plus antivirals
CONDITIONS
Official Title
Combined Light, ExVivo, and Antivirals for Recipients of Lungs From HBV Donors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Donor lung suitable for transplantation
- Donor is HBV SAg positive and/or HBV NAT positive
- Recipient is eligible and listed for lung transplant
- Recipient is HBV NAT negative
- Recipient provides written informed consent
- Recipient has received at least 3 prior doses of Hepatitis B vaccine or has anti-HBs \u226510 IU/mL
- Recipients with other co-morbid conditions are eligible if medically suitable for transplantation
You will not qualify if you...
- Donor is HIV positive
- Donor is HTLV 1/2 positive
- Donor has medical issues that normally exclude donation (e.g., cancer history, organ dysfunction)
- Recipient has chronic liver disease with more than stage 2 fibrosis
- Recipient participates in another interventional clinical trial
- Recipient is listed for combined transplant (e.g., heart-lung, lung-liver)
- Recipient has known allergy or contraindication to antiviral medications
- Recipient is Hepatitis B surface antigen or Hepatitis B core antibody positive pre-transplant
- Recipient is HIV positive
- Recipient has low serum IgA pre-transplant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Health Network, Toronto General Hospital
Toronto, Ontario, Canada, M5G 2C4
Actively Recruiting
Research Team
A
Atul Humar, MD, FRCPC
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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