Postoperative Radiotherapy with Kidney-Sparing Surgery for High-Risk Locally Advanced Ureteral Cancer

What this Trial Is About

Researchers are studying patients with locally advanced ureteral cancer who have high-risk factors, such as multifocal tumors or advanced stages. The study aims to analyze the safety and effectiveness of surgery that preserves the kidney combined with postoperative radiotherapy, compared to the traditional radical surgery that removes the kidney. The goal is to find a treatment that maintains kidney function and improves tolerance for later drug therapies without reducing cancer control. The study includes two groups one receiving kidney-sparing surgery followed by radiotherapy after the operation, and a comparison group undergoing radical surgery. Patients will have preoperative imaging like CT or MRI to determine disease stage. After surgery, patients may receive additional chemotherapy or radiotherapy based on their pathology and preferences. Participants will be closely monitored through follow-up visits to assess outcomes such as local recurrence-free survival at 1, 3, and 5 years, renal function around surgery and treatment, metastasis-free survival, overall survival, and recurrence in the bladder or opposite ureter. Adverse effects related to surgery and treatment will also be recorded. The total study duration spans several years with ongoing assessments to evaluate long-term safety and effectiveness.

Combined Postoperative Radiotherapy With Kidney Sparing Surgery for Locally Advanced High-risk Ureteral Cancer