Predicting Success of Breathing Tube Removal in ICU Patients Using RSBI and CALLY Index A Prospective Study Evaluating Respiratory and Immunonutritional Markers

What this Trial Is About

Researchers are investigating how well the Rapid Shallow Breathing Index RSBI combined with the CRP-Albumin-Lymphocyte CALLY index can predict success in weaning adult patients from mechanical ventilation in intensive care units. This observational study focuses on improving predictions by adding the CALLY index, which reflects a patients immune and nutritional status relative to inflammation, to the existing RSBI metric. The goal is to better identify the right timing for removing ventilator support and reduce the chances of needing reintubation. The study collects detailed clinical and laboratory data from about 105 patients at two hospitals. Participants are monitored during the process of weaning and a Spontaneous Breathing Trial SBT, with measurements including respiratory parameters, inflammation markers like CRP, albumin, and lymphocyte counts. The CALLY index is calculated as a ratio of immuno-nutritional reserves to systemic inflammation. Researchers observe participants for both immediate within 48 hours and late up to 7 days outcomes after extubation to capture any failures in weaning. Throughout the study, demographic and clinical severity data are gathered alongside ongoing respiratory assessments. The main outcome measured is the rate of successful weaning and respiratory stability up to 7 days after extubation, with secondary outcomes including mortality rates 28 days after enrollment. This comprehensive data collection aims to provide a more complete picture of factors influencing weaning success and improve clinical decision-making in intensive care.

Combined Predictive Value of RSBI and CALLY Index in Predicting Weaning Success in ICU Patients