Actively Recruiting
Combined Predictive Value of Rapid Shallow Breathing Index (RSBI) and CRP-Albumin-Lymphocyte (CALLY) Indices in Predicting the Success of Weaning From Mechanical Ventilation in Intensive Care Patients: A Prospective Observational Study
Led by Istanbul University - Cerrahpasa · Updated on 2026-05-11
105
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how well the Rapid Shallow Breathing Index (RSBI) combined with the CRP-Albumin-Lymphocyte (CALLY) index can predict success in weaning adult patients from mechanical ventilation in intensive care units. This observational study focuses on improving predictions by adding the CALLY index, which reflects a patient's immune and nutritional status relative to inflammation, to the existing RSBI metric. The goal is to better identify the right timing for removing ventilator support and reduce the chances of needing reintubation. The study collects detailed clinical and laboratory data from about 105 patients at two hospitals. Participants are monitored during the process of weaning and a Spontaneous Breathing Trial (SBT), with measurements including respiratory parameters, inflammation markers like CRP, albumin, and lymphocyte counts. The CALLY index is calculated as a ratio of immuno-nutritional reserves to systemic inflammation. Researchers observe participants for both immediate (within 48 hours) and late (up to 7 days) outcomes after extubation to capture any failures in weaning. Throughout the study, demographic and clinical severity data are gathered alongside ongoing respiratory assessments. The main outcome measured is the rate of successful weaning and respiratory stability up to 7 days after extubation, with secondary outcomes including mortality rates 28 days after enrollment. This comprehensive data collection aims to provide a more complete picture of factors influencing weaning success and improve clinical decision-making in intensive care.
CONDITIONS
Brief Title
Combined Predictive Value of RSBI and CALLY Index in Predicting Weaning Success in ICU Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 years and older
- Patients who have received invasive mechanical ventilation for at least 24 hours in the general intensive care unit
- Patients who meet standard clinical weaning criteria such as hemodynamic stability with minimal or no vasopressor support, adequate cough reflex, and absence of excessive airway secretions
- Patients deemed ready for a Spontaneous Breathing Trial by the attending physician
You will not qualify if you...
- Patients under the age of 18
- Patients with a known or detected pregnancy
- Patients with a diagnosis of malignancy
- Patients with neuromuscular diseases that could impair respiratory effort or muscle strength assessments such as Myasthenia Gravis, Amyotrophic Lateral Sclerosis, or Guillain-Barré syndrome
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 7 days post-extubation
Participants are observed during the weaning process from mechanical ventilation, with respiratory and laboratory parameters collected to assess readiness and stability.
Continuous monitoring during ICU stay with assessments around spontaneous breathing trials and extubation
Duration - Up to 28 days post enrollment
Participants are followed for survival and respiratory stability to capture both immediate and late-phase weaning outcomes.
Follow-up assessments to record survival and respiratory status
Trial Site Locations
Total: 1 location
1
Basaksehir Cam and Sakura City Hospital
Istanbul, Istanbul, Turkey (Türkiye), 34480
Actively Recruiting
Research Team
M
mahmut baran kasisari, medical doctor
T
tugba yesilyurt dogu, medical doctor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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