Actively Recruiting
Combined Recanalization Therapy for Acute Large Vessel Occlusion Stroke
Led by Tianjin Huanhu Hospital · Updated on 2025-08-11
64
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this clinical trial is to evaluate the efficacy and safety of combined recanalization therapy in patients who cannot be recanalized by acute large vessel occlusive stroke. The main questions it aims to answer are: 1、Proportion of subjects with mRs score of 0-1 at 90 days after surgery Participants will: 1、In acute large vessel occlusive stroke, if traditional means cannot be recanalized, combined recanalization surgery (including arteriotomy and thrombectomy, cerebrovascular bypass surgery) is performed.
CONDITIONS
Official Title
Combined Recanalization Therapy for Acute Large Vessel Occlusion Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 75 years
- Meets current guidelines indicating mechanical thrombectomy (MT)
- Modified Rankin Scale score of 2 or less before stroke
- Alberta Stroke Program Early CT Score (ASPECTS) of 6 or higher
- Middle cerebral artery (MCA) occlusion, with or without internal carotid artery (ICA) occlusion
- Mechanical thrombectomy was unsuccessful with Thrombolysis in Cerebral Infarction (TICI) score 0-1
- Time from stroke onset to craniotomy expected to be 24 hours or less
- Post-awakening stroke with mismatch between infarct zone and penumbra zone
You will not qualify if you...
- Presence of hemorrhagic vascular diseases such as intracranial aneurysm or vascular malformation, or planned cerebrovascular surgery that may affect cerebral blood flow or cause stroke
- Unstable angina, myocardial infarction, or congestive heart failure within the previous 6 months
- Pregnancy or perinatal period
- Hematologic disorders causing blood clotting problems
- Other diseases with life expectancy less than 2 years
- Previous intracranial or extracranial vascular bypass surgery
- Allergy to iodine or X-ray contrast media, creatinine over 3.0 mg/dl, or other reasons preventing arteriography
- Uncontrolled diabetes with fasting blood sugar over 16.7 mmol/L
- Uncontrolled high blood pressure with sitting systolic over 180 mmHg or diastolic over 110 mmHg
- Severe liver dysfunction with liver enzymes more than three times normal levels
- Platelet count less than 100 x 10^9 /L
- Participation in another clinical trial or use of trial drugs/devices within 30 days before screening
- Contraindications to general anesthesia or craniotomy
- Other medical conditions that might affect study safety or results, as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tianjin Huahu Hospital
Tianjin, Tianjin Municipality, China, 300060
Actively Recruiting
Research Team
G
Gao Kaiming
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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