Actively Recruiting
Combined Respiratory Training in Persons With ALS
Led by Nova Southeastern University · Updated on 2025-12-23
34
Participants Needed
1
Research Sites
162 weeks
Total Duration
On this page
Sponsors
N
Nova Southeastern University
Lead Sponsor
C
Congressionally Directed Medical Research Programs
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this interventional trial is to learn about lung volume recruitment (LVR) and expiratory muscle strength training (EMST) in a total of up to 39 patients diagnosed with ALS. The following aims will be addressed: 1. Determine the impact of combined LVR and EMST on cough strength and respiratory function in individuals with ALS. 2. Determine the impact of combined LVR and EMST on patient-reported dyspnea and bulbar impairment. 3. Describe the effect of combined LVR and EMST on patient- and caregiver reported burden and quality of life.
CONDITIONS
Official Title
Combined Respiratory Training in Persons With ALS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of probable or definite ALS by Revisited El-Escorial Criteria
- Disease duration from symptom onset of 2 years or less
- No prior experience with lung volume recruitment and expiratory muscle strength training
- Reduced peak cough flow compared to predicted values for age and gender
You will not qualify if you...
- History of stroke, head and neck cancer, or other disorders affecting swallowing or breathing
- Use of prescription cough assist or non-invasive ventilation devices
- Enrollment in other studies affecting cough or respiratory function
- Diagnosis of frontotemporal dementia or advanced cognitive impairment
- Tracheostomy placement or use of invasive mechanical ventilation
- Contraindications for respiratory training such as history of pneumothorax or severe chronic obstructive pulmonary disease
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Nova Southeastern University
Fort Lauderdale, Florida, United States, 33314
Actively Recruiting
Research Team
L
Lauren Tabor Gray, PhD
CONTACT
D
Donovan Mott
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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