Actively Recruiting
Safety and Efficacy of Combined Subcostal and Lateral Transversus Abdominis Plane Block for Postoperative Analgesia Versus Thoracic Epidural Anesthesia in Patients Undergoing Major Abdominal Cancer Surgery
Led by Assiut University · Updated on 2025-12-11
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate the safety and effectiveness of a combined subcostal and lateral transversus abdominis plane (TAP) block compared with thoracic epidural anesthesia (TEA) for pain relief after major abdominal cancer surgery. Postoperative pain is commonly managed by various methods, with TEA traditionally considered the standard due to its reliable pain control and additional benefits like reduced intestinal blockage and better lung function. TAP blocks are increasingly important in pain management and recovery protocols following surgery. Participants will be randomly assigned to one of two groups: one receiving an ultrasound-guided combined subcostal and lateral TAP block, and the other receiving an ultrasound-guided thoracic epidural anesthesia. Both methods involve precise ultrasound guidance to deliver anesthesia and are studied to compare their effects on postoperative pain control after major abdominal surgeries such as gastrectomy, colectomy, or hepatectomy. During the study, participants will be monitored for total morphine use within 24 hours after surgery, time to first need for additional pain relief, blood pressure and heart rate during surgery, level of pain after 24 hours, and any side effects occurring after surgery. The study includes double-blind procedures and random assignment, with follow-up assessments focused on safety and pain management outcomes. The trial is sponsored by Assiut University and will run until April 2026.
CONDITIONS
Brief Title
Combined Subcostal and Lateral Transversus Abdominis Plane Block for Postoperative Analgesia Versus Thoracic Epidural Analgesia in Patients Undergoing Major Abdominal Cancer Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 63 18 years
- Both sexes
- American Society of Anesthesiologists (ASA) physical status I-III
- Scheduled for major abdominal surgeries such as gastrectomy, colectomy, hepatectomy, cystectomy, total abdominal hysterectomy, nephrectomy, or pancreatectomy
You will not qualify if you...
- Intraoperative hemodynamic instability
- History or evidence of coagulopathy
- Infection or abdominal wall masses at injection site
- Morbid obesity
- Other medical conditions including mental illness or substance abuse
- Known allergy to local anesthetics
- Chronic opioid use or chronic pain conditions
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 2 hours during surgery and 24 hours postoperatively
Participants receive either a combined subcostal and lateral transversus abdominis plane block or thoracic epidural anesthesia as part of their postoperative pain management following major abdominal cancer surgery.
1 perioperative visit and monitoring during the first 24 hours after surgery
Trial Site Locations
Total: 1 location
1
Assiut University
Asyut, Egypt, 71515
Actively Recruiting
Research Team
B
Bahaa G Saad, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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