Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT05272488

A Combined Treatment of Manual Therapy and Nervous Vagus Stimulation in Patients With Myogenic Temporomandibular Disorders

Led by University of Alcala · Updated on 2026-05-01

60

Participants Needed

3

Research Sites

267 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Temporomandibular disorders (TMD) are one of the most important Public Health issues in the world and its incidence has increased over the years. The Physiotherapy and manual therapy techniques has shown its efficacy to reduce pain and to improve jaw functionality in patients with TMD. Until now, treatment targets has been the muscle and joint, but clinicians has not taken into account the innervation and how the nerve can have an influence in pain or jaw functionality. In this sense, it is known that there is a relationship between jaw innervation and vagus nerve, a parasympathetic nerve which is easily stimulable, due to its connection with the respiratory system, taking deep breaths using the diaphragm. Therefore, our hypothesis is that a treatment in which clinicians combine manual therapy and nerve vagus stimulation could have better effects (reducing pain, increasing range of motion in temporomandibular joints and improving quality of life in patients with TMD) than a isolated manual therapy treatment. With this purpose will be selected 20 subjects to participate in our study divided in two groups. Both groups will received 4 sessions of physiotherapy (one each 7 days during one month) and also will be thought to do own treatment those days the subjects does not come to the clinic until the study will have finished (the interventional period last two months). Both groups will received the same manual therapy techniques but only the experimental group will be treated with nerve vagus stimulation technique. One member of the group who will not participated in the interventions will be in charge of do evaluations (1 each month/ a total of 3 evaluations) following different questionaries to assess the primary variables of the study: chronic pain level, jaw functionality, physical symptoms level, range of motion and distress level.

CONDITIONS

Official Title

A Combined Treatment of Manual Therapy and Nervous Vagus Stimulation in Patients With Myogenic Temporomandibular Disorders

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Clinical diagnosis of myogenic pain according to the CD / TTM diagnostic criteria
  • Presence of pain during the last 30 days
  • Patients with decreased jaw function and mobility due to pain
  • Patients who have not received physiotherapy treatment in the last 3 weeks
  • Patients of legal age
Not Eligible

You will not qualify if you...

  • Patients with drug treatment: sedatives, anti-inflammatories, antidepressants, anxiolytics or muscle relaxants
  • Patients with cardiac pacemakers and implanted defibrillators
  • Patients diagnosed with severe cardiorespiratory and/or respiratory diseases, cancer, infections, or systemic pathologies
  • Clinical diagnosis of temporomandibular disorder of joint or mixed origin
  • Patients with psychiatric or psychological disorders, intellectual or motor deficiencies preventing correct exercise, following instructions, or understanding questionnaires
  • Patients with dental procedures scheduled during the study or surgery in the last 3 months
  • Patients whose pain is due to local or general trauma
  • Patients diagnosed with fibromyalgia, neuropathic pain, or degenerative diseases

AI-Screening

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Trial Site Locations

Total: 3 locations

1

Clinical University Physiotherapy and pain

Alcalá de Henares, Madrid, Spain, 2805

Actively Recruiting

2

Martinez-Merinero, Patricia

Alcalá de Henares, Madrid, Spain, 28805

Actively Recruiting

3

Physioterapy and Pain center research

Alcalá de Henares, Madrid, Spain, 28805

Actively Recruiting

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Research Team

P

Patricia Martinez-Merinero, PhD

CONTACT

D

Daniel Pecos-Martin, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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A Combined Treatment of Manual Therapy and Nervous Vagus Stimulation in Patients With Myogenic Temporomandibular Disorders | DecenTrialz