Actively Recruiting
Investigation of the Effect of Combined Upper Extremity Resistance and Aerobic Exercise Training on Arm Exercise Capacity, Peripheral Muscle Strength and Arm Functionality in Patients With Breast Cancer
Led by Hacettepe University · Updated on 2025-12-29
40
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Breast cancer is one of the most common cancers affecting women worldwide, responsible for a significant number of cancer cases and deaths. Advances in screening and treatment have improved survival rates, but many women experience side effects after treatment, including upper limb dysfunction and lymphoedema, which can impact daily activities and quality of life. This study aims to explore how combined upper extremity aerobic and resistance exercise training, compared to aerobic exercise alone, affects arm exercise capacity, muscle strength, arm functionality, sarcopenia, frailty, quality of life, and lymphoedema in breast cancer patients. Participants will be randomly assigned to one of two groups: one group will engage in a 12-week program of upper extremity aerobic exercise training with sessions three times a week lasting 25 minutes each, while the other group will receive the same aerobic exercise combined with progressive resistance training using elastic resistance bands gradually increased over 12 weeks. The study will assess the effects of these exercise programs on various physical and health outcomes related to breast cancer treatment side effects. During the study, participants will be evaluated over one year, including tests such as the 6-minute Pegboard and Ring Test and measures of maximal arm exercise capacity. Researchers will also assess quality of life, peripheral muscle strength, arm functionality, sarcopenia, frailty, lymphoedema, and other health parameters. This monitoring will help determine how the exercise programs influence recovery and physical function after breast cancer treatment.
CONDITIONS
Brief Title
Combined Upper Extremity Resistance and Aerobic Exercise Training in Patients With Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- To be between 18-80 years old
- Volunteering to participate in the research
- At least 15 months after breast cancer surgery
- No problems in reading and/or understanding the scales and being able to co-operate with the tests
- Physically inactive (less than 60 minutes of structured exercise per week)
You will not qualify if you...
- Presence of active infection
- Presence of bilateral breast cancer
- History of surgical, neurological, or orthopaedic problems affecting upper extremity functionality other than breast cancer surgery
- Having a neurological disease or other clinical diagnosis affecting cognitive status
- Musculoskeletal and neurological disease affecting exercise performance, symptomatic heart disease, previous lung surgery, and malignant disease
- Presence of unstable hypertension or diabetes mellitus
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 weeks
Participants undergo a 12-week exercise training program involving either upper extremity aerobic exercise alone or combined with progressive resistance training to improve arm exercise capacity, muscle strength, and arm functionality.
3 exercise sessions per week, 25 minutes per session
Duration - Up to 1 year after treatment
Participants are monitored for outcomes including arm exercise capacity, quality of life, muscle strength, upper extremity functionality, sarcopenia, frailty status, and lymphoedema for up to one year after treatment.
Visits scheduled as per study protocol for assessments
Trial Site Locations
Total: 1 location
1
Hcettepe University
Ankara, State, Turkey (Türkiye), 06100
Actively Recruiting
Research Team
E
Ebru Calik Kutukcu, PhD
N
Naciye Vardar-Yagli, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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