Study of Combined PRP and Hyaluronic Acid Injections for Treating Knee Osteoarthritis in Adults Aged 40 to 75

What this Trial Is About

Researchers are evaluating the treatment of knee osteoarthritis in adults aged 40 to 75 through a double-blind, randomized controlled clinical trial. The study aims to compare the effectiveness and safety of combined platelet-rich plasma PRP with hyaluronic acid HA injections against PRP alone or HA alone. This approach is designed to improve symptoms in patients with degenerative knee cartilage conditions who have not responded to conservative treatments. Participants will be randomly assigned to one of three groups one receiving a single injection of PRP combined with HA, another receiving PRP alone, and the third receiving HA alone. All patients will undergo blood collection to prepare PRP, although only the PRP and PRPHA groups will receive PRP injections. The HA injection is administered first in the combined group, followed by PRP, to maintain sterility and ensure proper delivery. During the study, participants will be assessed before treatment and at 1, 3, 6, 12, and 24 months post-injection. Medical staff will perform clinical evaluations, including functional questionnaires and objective measures like range of motion and knee circumference. The main outcome measured is the Western Ontario and McMaster Universities Osteoarthritis Index WOMAC at 12 months, with additional assessments of pain, activity level, and quality of life occurring throughout the follow-up period. The total participation may extend up to two years to monitor safety and treatment effects.

Combined Use of PRP and Hyaluronic Acid for Infiltrative Treatment of Patients With Knee Osteoarthritis