Actively Recruiting
Combining Aspirin With Ticagrelor or Cilostazol in Large-vessel Minor Stroke or TIA
Led by Kafrelsheikh University · Updated on 2025-09-18
900
Participants Needed
2
Research Sites
59 weeks
Total Duration
On this page
Sponsors
K
Kafrelsheikh University
Lead Sponsor
E
El-Sahel Teaching Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Along with the current clinical trial, the efficacy and safety of a 180 mg loading dose of ticagrelor administered within 24 hours of the first-ever large-vessel minor stroke or TIA compared to 200mg cilostazol were assessed through NIHSS, mRS, and possible adverse effects.
CONDITIONS
Official Title
Combining Aspirin With Ticagrelor or Cilostazol in Large-vessel Minor Stroke or TIA
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 75 years
- First-ever large-vessel minor ischemic stroke or transient ischemic attack (TIA)
- Received antiplatelet treatment within 24 hours of stroke onset
- Not eligible for rt-PA treatment
- Both genders included
You will not qualify if you...
- No follow-up for 90 days after enrollment
- NIHSS score less than 5 or rapidly resolving symptoms before imaging
- History of persistent or recurrent central nervous system diseases such as epilepsy, meningioma, multiple sclerosis, or head trauma with lasting neurological deficits
- Clinical seizures at stroke onset
- Major organ failure, active cancer, or acute myocardial infarction within past 6 weeks
- Use of warfarin, regular ticagrelor within the week before admission, or chemotherapy within the past year
- Active peptic ulcers, recent gastrointestinal surgery, or bleeding within the last year
- Major surgery within the last three months
- Known allergy to study drugs
- INR greater than 1.4 or PT greater than 18
- Blood glucose less than 50 or greater than 400 mg/dL
- Blood pressure less than 90/60 or greater than 185/110 mmHg on admission
- Platelet count less than 100,000
- Pregnant or lactating patients
- Stroke due to venous thrombosis, cardiac arrest, or severe low blood pressure
- Contraindications to study drugs
AI-Screening
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Trial Site Locations
Total: 2 locations
1
El-sahel teaching hospital
Cairo, Egypt, 22514
Actively Recruiting
2
Kafr Elsheikh University Hospital
Kafr ash Shaykh, Egypt, 33511
Actively Recruiting
Research Team
M
mohamed G. Zeinhom, MD
CONTACT
S
sherihan R. ahmed, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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