Actively Recruiting

Phase 3
Age: 18Years - 75Years
All Genders
NCT06591338

Combining Aspirin With Ticagrelor or Clopidogrel in Large-vessel Minor Stroke or TIA

Led by Kafrelsheikh University · Updated on 2025-09-05

900

Participants Needed

1

Research Sites

57 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Along with the current clinical trial, the efficacy and safety of a 180 mg loading dose of ticagrelor administered within 24 hours of the first-ever large-vessel minor stroke or TIA compared to 300 mg clopidogrel were assessed through NIHSS, mRS, and possible adverse effects.

CONDITIONS

Official Title

Combining Aspirin With Ticagrelor or Clopidogrel in Large-vessel Minor Stroke or TIA

Who Can Participate

Age: 18Years - 75Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Both genders aged 18 to 75 years
  • First-ever large-vessel minor ischemic stroke or transient ischemic attack
  • Received antiplatelet treatment within 24 hours of ischemic stroke onset
  • Not eligible for rt-PA treatment
Not Eligible

You will not qualify if you...

  • Not followed up for 90 days after enrollment
  • NIHSS score less than 5 or rapidly resolving symptoms before imaging
  • Known persistent or recurrent central nervous system disorders (epilepsy, meningioma, multiple sclerosis, head trauma with lasting deficits)
  • Clinical seizures at stroke onset
  • Major organ failure or active cancer
  • Acute myocardial infarction within 6 weeks before enrollment
  • Use of warfarin, regular ticagrelor in the week before admission, or chemotherapy within the past year
  • Active peptic ulcers, recent gastrointestinal surgery, or bleeding history within 1 year
  • Major surgery within the last 3 months
  • Known allergy to study drugs
  • Abnormal blood clotting tests (INR > 1.4, PT > 18)
  • Blood glucose below 50 or above 400 mg/dL
  • Blood pressure below 90/60 or above 185/110 mmHg at admission
  • Platelet count below 100,000
  • Pregnancy or lactation
  • Stroke due to venous thrombosis, cardiac arrest, or severe low blood pressure
  • Contraindications to study drugs

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Kafr Elsheikh University Hospital

Kafr ash Shaykh, Egypt, 33511

Actively Recruiting

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Research Team

M

mohamed G. Zeinhom, MD

CONTACT

S

sherihan R. ahmed, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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