Actively Recruiting

Phase 3
Age: 18Years - 75Years
All Genders
NCT06591312

Combining Aspirin With Ticagrelor or Clopidogrel in Minor Stroke or TIA

Led by Kafrelsheikh University · Updated on 2024-09-19

900

Participants Needed

1

Research Sites

125 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Along with the current clinical trial, the efficacy and safety of a 180 mg loading dose of ticagrelor administered within 24 hours of the first-ever minor stroke or TIA compared to 300 mg clopidogrel were assessed through NIHSS, mRS, and possible adverse effects.

CONDITIONS

Official Title

Combining Aspirin With Ticagrelor or Clopidogrel in Minor Stroke or TIA

Who Can Participate

Age: 18Years - 75Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults aged 18 to 75 years
  • First-ever minor ischemic stroke or transient ischemic attack (TIA)
  • Received antiplatelet treatment within 24 hours of stroke onset
  • Not eligible for rt-PA treatment
  • Both genders included
Not Eligible

You will not qualify if you...

  • Not available for 90-day follow-up after enrollment
  • NIHSS score less than 5 or rapidly resolving symptoms before imaging
  • History of persistent or recurrent central nervous system diseases (e.g., epilepsy, meningioma, multiple sclerosis, head trauma with residual deficits)
  • Clinical seizures at stroke onset
  • Major organ failure, active malignancies, or myocardial infarction within previous six weeks
  • Use of warfarin, regular ticagrelor before admission, or chemotherapy within the past year
  • Active peptic ulcers, recent gastrointestinal surgery, or bleeding history within the last year
  • Major surgery within the last three months
  • Known allergy to study drugs
  • Abnormal blood clotting tests (INR > 1.4 or PT > 18)
  • Blood glucose below 50 or above 400 mg/dL
  • Blood pressure below 90/60 or above 185/110 mmHg on admission
  • Platelet count below 100,000
  • Pregnant or lactating women
  • Stroke due to venous thrombosis or following cardiac arrest or severe hypotension
  • Contraindications to study drugs

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Kafr Elsheikh University Hospital

Kafr ash Shaykh, Egypt, 33511

Actively Recruiting

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Research Team

M

mohamed G. Zeinhom, MD

CONTACT

S

sherihan R. ahmed, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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