Using MRI and Transcranial Direct Current Stimulation to Study Brain Networks in Adults With Neuropathic Pain

What this Trial Is About

Neuropathic pain, often caused by peripheral neuropathy such as diabetic or chemotherapy-induced neuropathy, can be severe and difficult to manage since fewer than half of patients respond well to medication. This research aims to study the effects of transcranial direct current stimulation tDCS, a non-invasive brain stimulation technique, on neuropathic pain. The study will explore how tDCS affects brain networks involved in pain, which may help improve understanding and treatment approaches for patients with this condition. The study involves applying tDCS through an MRI-compatible device during functional magnetic resonance imaging fMRI scans. The stimulation targets two brain areas the primary motor cortex M1 and the dorsolateral prefrontal cortex DLPFC. The stimulation will be given at 2 milliamps for 5 to 15 minutes. This simultaneous tDCS-fMRI approach helps researchers observe brain responses and changes in cortical activity related to pain perception. Participants will undergo brain scans while receiving tDCS and will be monitored for changes in brain functional connectivity and neuropathic pain intensity five days after stimulation. The study includes assessments of brain activity patterns and neuroplasticity related to pain. Participants need to avoid caffeine, alcohol, tea, and certain drugs before sessions. The total involvement includes initial stimulation sessions and follow-up evaluations over several days, with safety and consent carefully managed throughout.

Combining fMRI and tDCS in Neuropathic Pain