Actively Recruiting
Combining fMRI and tDCS in Neuropathic Pain
Led by National Taiwan University Hospital · Updated on 2024-02-01
150
Participants Needed
1
Research Sites
365 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The proposed project aims to explore possible neuromodulatory effects of transcranial direct current stimulation (tDCS) on neuropathic pain caused by peripheral neuropathy. tDCS will be performed through an MRI-compatible stimulation setting during functional magnetic resonance imaging (fMRI) scanning. The stimulation target of tDCS will be the primary motor cortex (M1) and the dorsolateral prefrontal cortex (DLPFC). We expect that results from the current project will advance the understanding of neuromodulatory mechanisms of tDCS and facilitate the development of treatment strategies for patients with neuropathic pain.
CONDITIONS
Official Title
Combining fMRI and tDCS in Neuropathic Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 20 or older and 90 or younger
- Ability to give informed consent
- Neuropathic pain and/or nonpainful sensory symptoms caused by peripheral neuropathy confirmed by clinical symptoms, nerve conduction study, autonomic function test, quantitative sensory test, or skin biopsy
- Stroke involving somatosensory pathway confirmed by neuroimaging
- Agree not to consume caffeine, alcohol, tea, or drugs affecting the nervous system for 48 hours before each study session
You will not qualify if you...
- Severe systemic diseases such as severe ischemic heart disease or congestive heart failure (left ventricular ejection fraction < 30%), severe lung diseases with dyspnea, severe generalized edema, or systemic infection
- Major neurological disorders including brain tumor, head trauma, or nervous system infection or inflammation
- Major depression or other major mental disorders
- Presence of cardiac pacemaker, brain stimulator, aneurysm clips, or metal implants in the head unless certified MRI-compatible
- Pregnancy
- Claustrophobia or other contraindications to MRI
- Inability to give informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Taiwan University Hospital
Taipei, Taiwan, 112
Actively Recruiting
Research Team
S
Sung-Tsang Hsieh, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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