Actively Recruiting

Phase Not Applicable
Age: 21Years +
All Genders
Healthy Volunteers
ID06787937

Communicating About Nicotine and Differential Risks of Tobacco Products in Priority Populations

Led by Georgia State University · Updated on 2025-10-29

1230

Participants Needed

2

Research Sites

N/A

Total Duration

On this page

Sponsors

G

Georgia State University

Lead Sponsor

E

Emory University

Collaborating Sponsor

AI-Summary

What this Trial Is About

Researchers are studying how a messaging campaign about reduced nicotine cigarettes and related policies, combined with the use of very low nicotine cigarettes (VLNCs), affects smoking habits and attitudes among adult smokers. The study focuses on smokers from three groups: those with recent serious psychological distress, those with low socioeconomic status, and those not in either group. The primary goal is to see if messages alongside VLNC use reduce cigarette smoking more than VLNC use alone. Participants will be randomly assigned to one of two groups: one group will receive VLNCs with exposure to messages about VLNCs and reduced nicotine policies through inserts in cigarette packs, printed ads, and videos during weekly visits. The other group will receive VLNCs without these messages but will see neutral messages like bottled water ads. The study includes a 1-week baseline period with full nicotine cigarettes, followed by a 4-week period of receiving VLNCs with or without messaging. During the study, participants attend weekly visits to complete surveys, provide breath carbon monoxide samples, and receive their VLNC supply. They also complete brief daily surveys via text messages throughout the baseline and 4-week study periods. Researchers will measure cigarettes smoked per day at week 4 and assess other outcomes such as use of other tobacco products, quit attempts, and attitudes about smoking VLNCs. The total study duration is 5 weeks including baseline and intervention phases.

CONDITIONS

Brief Title

Communicating About Nicotine Reduction in Cigarettes

Who Can Participate

Age: 21Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 21 years or older
  • Current smoker, defined as smoking on 27 or more days in the past 30 and having smoked at least 100 cigarettes in lifetime
  • Expired breath carbon monoxide level of 6 ppm or higher to confirm regular smoking
  • Able to speak, read, and write in English
  • Available to participate for the full study period
  • Willing to try research cigarettes as part of the trial
Not Eligible

You will not qualify if you...

  • Pregnant or currently breastfeeding
  • Living in the same household as another study participant
  • Unwilling to use the research cigarettes provided during the trial

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Baseline Period

Duration - 1 week

Participants complete baseline surveys, provide expired breath carbon monoxide samples, and receive a 1-week supply of full nicotine cigarettes while logging daily smoking behaviors.

1 baseline visit (in-person) and daily online surveys

Randomization and Treatment

Duration - 4 weeks

Participants are randomized to receive very low nicotine cigarettes (VLNCs) with or without messaging about VLNCs and reduced nicotine policy. Weekly visits include questionnaires, expired breath carbon monoxide samples, and receiving a 14-day supply of VLNCs with or without messaging.

1 randomization visit and 4 weekly visits (all in-person), plus daily online surveys

Trial Site Locations

Total: 2 locations

1

Georgia State university

Atlanta, Georgia, United States, 30303

Actively Recruiting

2

Emory University

Atlanta, Georgia, United States, 30322

Actively Recruiting

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Research Team

L

Lyudmila Popova, Ph.D.

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

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Frequently Asked Questions

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Published Research Related To This Trial

Nicotine Intervention and Communication for Empowering Reduction (NICER): study protocol for a randomized controlled trial among priority populations of people who smoke.

Di Pei, Aubrey Juris, Prudence Nkansah...

https://pubmed.ncbi.nlm.nih.gov/41250122