Study on Messaging and Use of Very Low Nicotine Cigarettes to Change Smoking Habits in Adult Smokers
Led by Georgia State University · Updated on 2025-10-29
1230
Participants Needed
2
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are studying how a messaging campaign about reduced nicotine cigarettes and related policies, combined with the use of very low nicotine cigarettes VLNCs, affects smoking habits and attitudes among adult smokers. The study focuses on smokers from three groups those with recent serious psychological distress, those with low socioeconomic status, and those not in either group. The primary goal is to see if messages alongside VLNC use reduce cigarette smoking more than VLNC use alone.
Participants will be randomly assigned to one of two groups one group will receive VLNCs with exposure to messages about VLNCs and reduced nicotine policies through inserts in cigarette packs, printed ads, and videos during weekly visits. The other group will receive VLNCs without these messages but will see neutral messages like bottled water ads. The study includes a 1-week baseline period with full nicotine cigarettes, followed by a 4-week period of receiving VLNCs with or without messaging.
During the study, participants attend weekly visits to complete surveys, provide breath carbon monoxide samples, and receive their VLNC supply. They also complete brief daily surveys via text messages throughout the baseline and 4-week study periods. Researchers will measure cigarettes smoked per day at week 4 and assess other outcomes such as use of other tobacco products, quit attempts, and attitudes about smoking VLNCs. The total study duration is 5 weeks including baseline and intervention phases.
CONDITIONS
Brief Title
Communicating About Nicotine Reduction in Cigarettes
Research Team
L
Lyudmila Popova, Ph.D.
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match. Sign up to get personalized trial recommendations delivered to your inbox.
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
Factors
VLNC + messages
VLNC only
Standard cessation messaging
What it is
Use of very low nicotine cigarettes combined with a messaging campaign about nicotine reduction policy
Use of very low nicotine cigarettes without exposure to any messages about policy
Behavioural counselling and pharmacotherapy-based messaging as recommended in current cessation guidelines
Role in trial
Experimental intervention arm receiving messaging campaign along with VLNCs
Control arm receiving VLNCs with neutral control messages
Not part of the trial; represents current recommended messaging practices
Primary use
To test whether messaging enhances effects of VLNCs on smoking behavior and perceptions
To serve as a comparison to assess messaging impact while using VLNCs
Represents established smoking cessation messaging frameworks
How it is given or performed
Messages delivered via pack inserts, print ads and videos during weekly visits while providing VLNCs
VLNCs provided weekly with neutral messages such as bottled water ads
Behavioural support and messaging typically delivered by trained professionals or via digital tools
Evidence status
Effect on misperceptions and smoking behavior is under investigation; not yet established
Effect of VLNCs without messaging is under study, impact not yet published
Behavioural support combined with pharmacotherapy has demonstrated effectiveness
Important limitations
Messaging effects combined with VLNCs are being tested; results pending
VLNC delivery without messaging may not address misperceptions about harm
Standard messaging may not address novel nicotine reduction policies or VLNC perceptions
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
Who Can Participate
Age: 21Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
Age 21 years or older
Current smoker, defined as smoking on 27 or more days in the past 30 and having smoked at least 100 cigarettes in lifetime
Expired breath carbon monoxide level of 6 ppm or higher to confirm regular smoking
Able to speak, read, and write in English
Available to participate for the full study period
Willing to try research cigarettes as part of the trial
You will not qualify if you...
Pregnant or currently breastfeeding
Living in the same household as another study participant
Unwilling to use the research cigarettes provided during the trial
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Baseline Period
Duration - 1 week
Participants complete baseline surveys, provide expired breath carbon monoxide samples, and receive a 1-week supply of full nicotine cigarettes while logging daily smoking behaviors.
1 baseline visit (in-person) and daily online surveys
Randomization and Treatment
Duration - 4 weeks
Participants are randomized to receive very low nicotine cigarettes (VLNCs) with or without messaging about VLNCs and reduced nicotine policy. Weekly visits include questionnaires, expired breath carbon monoxide samples, and receiving a 14-day supply of VLNCs with or without messaging.
1 randomization visit and 4 weekly visits (all in-person), plus daily online surveys
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Similar Trials
Group Therapy Using Dialectical Behavior Skills to Help Adults With Cancer Reduce or Quit Smoking
Study on Messaging and Use of Very Low Nicotine Cigarettes to Change Smoking Habits in Adult Smokers
Mobile Health Program to Help Young Adults Quit Electronic Cigarette Use
Includes Support and Nicotine Replacement Therapy Options
For Adults Aged 18 to 26 Years
Study of Ads to Help Adults Quit Both Cigarettes and E-cigarettes
Comparing Messages to Quit Simultaneously or One After the Other
Have more questions? Get in touch with our team for quick support
Published Research Related To This Trial
Nicotine Intervention and Communication for Empowering Reduction (NICER): study protocol for a randomized controlled trial among priority populations of people who smoke.