Actively Recruiting
Communication Bridge: Optimizing an Evidence-based Intervention for Individuals With Primary Progressive Aphasia
Led by University of Chicago · Updated on 2026-06-01
200
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Chicago
Lead Sponsor
W
Western University, Canada
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating two evidence-based speech-language therapy treatments for adults with mild to moderate Primary Progressive Aphasia (PPA). The study aims to better understand how these therapies affect communication abilities in people with PPA. It uses a randomized controlled trial design and involves participants and their engaged care partners. Participants will receive a laptop with necessary applications and access to Communication Bridge, a personalized web program to practice home exercises supporting the therapy. They will attend up to 20 speech therapy sessions with a licensed speech therapist and undergo up to 10 evaluations over about 17 months. The study compares an experimental dyadic intervention involving both the person with PPA and their partner, with a control intervention focusing on the person with PPA alone using fixed speech therapy activities. During the study, participants will complete assessments of communication participation and caregiver burden at five time points up to 18 months. The study includes regular monitoring through interviews, standardized tests, and use of the web application. There are no costs to participate, and medical records will be reviewed to confirm eligibility.
CONDITIONS
Brief Title
Communication Bridge 3 Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Primary Progressive Aphasia confirmed by neurologist and supporting medical assessments
- English as the primary language used in daily communication
- Adequate hearing with or without aid to communicate in a crowded room
- Adequate vision with or without aid to read newspapers or similar materials
- Ability to pass technology screening and use video conference and Communication Bridge web application
- Geriatric Depression Scale score of 9 or less
- Mild to moderate PPA confirmed by speech-language pathologist interview and standardized tests
- Co-enrolled communication partner is 18 years or older
- Co-enrolled partner speaks English as primary language
- Co-enrolled partner has adequate hearing for communication
- Co-enrolled partner can use technology for video conference and web application
You will not qualify if you...
- Diagnosis of dementia other than Primary Progressive Aphasia
- Currently enrolled in an outside speech language therapy program during the study
- Communication partner has a pre-existing communication impairment such as aphasia or dementia that would affect participation
- Medical records will be reviewed to confirm eligibility
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit (in-person or virtual)
Duration - Approximately 17 months
Participants receive speech therapy through either the Communication Bridge™ dyadic intervention or an impairment-focused intervention, including up to 20 therapy sessions and use of a personalized web application to practice home exercises.
Up to 10 evaluation visits and 20 speech therapy sessions (in-person or virtual)
Trial Site Locations
Total: 1 location
1
University of Chicago - American School Building
Chicago, Illinois, United States, 60637
Actively Recruiting
Research Team
M
Matthew Bona, MPH
E
Emily Cummings
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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