Actively Recruiting

Phase 3
Age: 18Years +
All Genders
NCT07449936

COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME

Led by EyePoint Pharmaceuticals, Inc. · Updated on 2026-05-06

240

Participants Needed

46

Research Sites

136 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.

CONDITIONS

Official Title

COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults aged 18 years or older
  • Diagnosis of macular edema associated with diabetic retinopathy in the study eye
  • Best-corrected visual acuity (BCVA) between 35 letters (20/200) and 78 letters (20/32) on ETDRS chart in the study eye at screening and baseline
  • For previously treated patients: at least 1 anti-VEGF injection in past 12 months
  • Last anti-VEGF treatment for diabetic macular edema must have been at least 12 weeks before screening
Not Eligible

You will not qualify if you...

  • Best-corrected visual acuity (BCVA) less than 30 letters (20/250) on ETDRS chart in the fellow eye

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 46 locations

1

California Retina Consultants

Bakersfield, California, United States, 93309

Actively Recruiting

2

The Retina Partners

Encino, California, United States, 91436

Actively Recruiting

3

Global Research Management, Inc.

Glendale, California, United States, 91204

Actively Recruiting

4

Northern California Retina Vitreous Associates Medical Group INC.

Mountain View, California, United States, 94040

Actively Recruiting

5

Retina Consultants of San Diego

Poway, California, United States, 92064

Actively Recruiting

6

California Eye Specialists Medical Group, Inc.

Redlands, California, United States, 92373

Actively Recruiting

7

Retinal Consultants Medical Group - Parkcenter Drive

Sacramento, California, United States, 95825

Actively Recruiting

8

Retinal Consultants Medical Group

Sacramento, California, United States, 95841

Actively Recruiting

9

Retina Consultants of Southern Colorado

Colorado Springs, Colorado, United States, 80909

Actively Recruiting

10

Colorado Retina Associates

Lakewood, Colorado, United States, 80228

Actively Recruiting

11

Advance Medical Research Group, Inc

Deerfield Beach, Florida, United States, 33064

Actively Recruiting

12

Eye Associates of Pinellas

Pinellas Park, Florida, United States, 33782

Actively Recruiting

13

Southern Vitreoretinal Associates

Tallahassee, Florida, United States, 32308

Actively Recruiting

14

Retina Specialists of Tampa

Wesley Chapel, Florida, United States, 33544

Actively Recruiting

15

Georgia Retina

Marietta, Georgia, United States, 30060

Actively Recruiting

16

Retina Consultants of Hawaii

‘Aiea, Hawaii, United States, 96701

Actively Recruiting

17

Red River Research Partners

Plainfield, Illinois, United States, 60586

Actively Recruiting

18

Midwest Eye Institute - Carmel

Carmel, Indiana, United States, 11220

Actively Recruiting

19

Haik Humble Eye Center

West Monroe, Louisiana, United States, 71291

Actively Recruiting

20

Retina Group of Washington

Chevy Chase, Maryland, United States, 20815

Actively Recruiting

21

Cumberland Valley Retina Consultants

Hagerstown, Maryland, United States, 21740

Completed

22

Retina Specialists - Towson

Towson, Maryland, United States, 21204

Actively Recruiting

23

New England Retina Consultants

Springfield, Massachusetts, United States, 01107

Actively Recruiting

24

Retina Associates of Michigan

Grand Blanc, Michigan, United States, 48439

Actively Recruiting

25

Foundation for Vision Research

Grand Rapids, Michigan, United States, 49546

Actively Recruiting

26

NJRetina Care Center - Teaneck

Teaneck, New Jersey, United States, 07666

Actively Recruiting

27

NJ Retina - Toms River

Toms River, New Jersey, United States, 08755

Actively Recruiting

28

Retina Associates of Western New York

Rochester, New York, United States, 14620

Actively Recruiting

29

VRCNY/Long Island Vitreoretinal Consultants

Westbury, New York, United States, 11590

Actively Recruiting

30

Asheville Eye Associates - Regional Medical Park

Asheville, North Carolina, United States, 28803

Actively Recruiting

31

Cape Fear Retinal Associates, PC

Wilmington, North Carolina, United States, 28401

Actively Recruiting

32

Piedmont Retina Specialists, P.A. - Winston-Salem Office

Winston-Salem, North Carolina, United States, 27103

Actively Recruiting

33

Tulsa Retina Consultant

Tulsa, Oklahoma, United States, 74114

Actively Recruiting

34

Erie Retina Research

Erie, Pennsylvania, United States, 16507

Actively Recruiting

35

Charleston Neuroscience Institute - Beaufort

Beaufort, South Carolina, United States, 29902

Actively Recruiting

36

Retina Consultants of Carolina P.A

Greenville, South Carolina, United States, 29605

Actively Recruiting

37

Tennessee Retina

Nashville, Tennessee, United States, 37203

Actively Recruiting

38

Retina Research Institute of Texas Integrated Clinical Research

Abilene, Texas, United States, 79606

Actively Recruiting

39

Texas Retina Associates

Dallas, Texas, United States, 75231

Actively Recruiting

40

Mt. Olympus Medical Research

Houston, Texas, United States, 77479

Actively Recruiting

41

Retina Consultants of Texas

Katy, Texas, United States, 77494

Actively Recruiting

42

Texas Retina Associates

Plano, Texas, United States, 75075

Actively Recruiting

43

Retina Consultants of Texas

Schertz, Texas, United States, 78154

Actively Recruiting

44

Retina Associates of Utah

Salt Lake City, Utah, United States, 84107

Actively Recruiting

45

Salt Lake Retina

West Jordan, Utah, United States, 84088

Actively Recruiting

46

Piedmont Eye Center

Lynchburg, Virginia, United States, 24502

Actively Recruiting

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Research Team

R

Ramiro Ribeiro, MD, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

QUADRUPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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