Actively Recruiting
Comparative Acute Effects of R-MDMA and S-MDMA in Healthy Participants
Led by University Hospital, Basel, Switzerland · Updated on 2025-07-30
24
Participants Needed
1
Research Sites
65 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Racemic ±3,4-methylenedioxymethamphetamine (MDMA) is a psychoactive substance and prototypical empathogen acutely inducing feelings of heightened mood, empathy, trust and closeness to others. These acute subjective effects of MDMA may be helpful to assist psychotherapy and MDMA has been investigated in phase 3 trials as a possible treatment in post-traumatic stress disorder.
CONDITIONS
Official Title
Comparative Acute Effects of R-MDMA and S-MDMA in Healthy Participants
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 65 years
- Good understanding of the German language
- Understanding of procedures and risks associated with the study
- Willing to adhere to the protocol and sign the consent form
- Willing to refrain from using illicit psychoactive substances during the study
- Willing not to operate heavy machinery within 48 hours after receiving study medication
- Willing to use effective birth control during study participation
- Body mass index between 18 and 34.9 kg/m2
You will not qualify if you...
- Having a relevant chronic or acute medical condition
- Current or past major psychiatric disorders such as bipolar disorder, schizophrenia, depression, or anxiety
- Psychotic disorder or bipolar disorder in first-degree relatives
- High blood pressure (above 140/90 mmHg) or low blood pressure (below 85 mmHg)
- Illicit substance use more than 20 times or any use within the last month (excluding cannabis)
- Pregnancy or currently breastfeeding
- Participation in another clinical trial within the last 30 days
- Use of medications that may interfere with the study drugs
- Smoking more than 10 cigarettes per day
- Drinking more than 15 alcoholic drinks per week
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University Hospital Basel
Basel, Canton of Basel-City, Switzerland, 4031
Actively Recruiting
Research Team
M
Matthias E Liechti, Prof. Dr. MD
CONTACT
C
Carolin R Mayer
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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