Comparison of Morphine and Tafalgin for Pain Relief After Coronary Artery Bypass Surgery CABG in Adults

What this Trial Is About

Researchers are evaluating postoperative pain relief methods in patients undergoing coronary artery bypass grafting CABG. This clinical trial compares the effects of tafalgin tyrosyl-D-arginyl-phenylalanyl-glycine amide with morphine to see if tafalgin reduces pain scores similarly to morphine. The study also monitors the medical problems participants may experience while using tafalgin. This trial is interventional and randomized with a single-blind design. Participants are assigned to one of two groups one group receives a single subcutaneous dose of morphine 10 mg based on a pain score greater than 3 within 24 hours after CABG. The other group receives a single subcutaneous dose of tafalgin 0.4 mg under the same pain score condition and timeframe. The trial focuses on early postoperative pain control in the first 24 hours after surgery. During the study, researchers assess pain using the Visual Analogue Scale VAS 24 hours after CABG. They also evaluate arterial blood gases, including pH, oxygen levels PaO2, and carbon dioxide levels PaCO2, as well as hemodynamic parameters like intra-arterial blood pressure and heart rate. Participants are monitored closely for safety and efficacy during this period. The study is scheduled to start in December 2025 and continue until March 2026.

Comparative Analysis of Analgesic Approaches in the Early Period After CABG