Actively Recruiting
Comparative Analysis of Healing Outcomes Between Two Bone Graft Materials in Socket Preservation Procedure
Led by Pharos University in Alexandria · Updated on 2026-01-20
18
Participants Needed
1
Research Sites
12 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to compare the healing outcomes of two different bovine bone graft materials used in socket preservation procedures after tooth extraction. The study focuses on maintaining the volume of bone and gum tissues, which often decrease following tooth removal. Researchers will evaluate both clinical and microscopic differences between an allograft and a xenograft in alveolar ridge preservation. Participants will be randomly assigned to one of two groups: one receiving the allograft material and the other the xenograft. All procedures are performed under local anesthesia and involve careful tooth extraction, graft placement, and coverage with a collagen membrane. After surgery, patients will receive antibiotics, pain relief, and oral rinses, followed by suture removal two weeks later. Follow-up scans will be done at 2-3 months, and bone biopsies will be taken to assess healing before dental implants are placed. Participants will undergo initial dental exams and hygiene treatment before surgery. Researchers will use 3D imaging to measure changes in bone width and thickness over time. Biopsies will be analyzed to study bone healing at the microscopic level. The primary outcome is the change in ridge width after 2-3 months, and secondary outcomes include detailed bone tissue analysis. The total study participation spans from initial evaluation through implant placement after healing assessment.
CONDITIONS
Brief Title
Comparative Analysis of 2 Bone Graft Materials in Socket Preservation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Systemically healthy individuals
- Non-smokers
- Age between 21 and 50 years
- Indicated for tooth extraction and socket preservation
- Good oral hygiene with full-mouth plaque score less than 20%
- Willingness to participate and provide informed consent
You will not qualify if you...
- Stage III or IV periodontitis
- Active periodontal or periapical infection
- Severely resorbed sockets with buccal bone height less than 5 mm
- Smoking more than 10 cigarettes per day
- Pregnancy
- Systemic conditions or medications affecting bone metabolism
AI-Screening
AI-Powered Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 2 weeks
Participants undergo tooth extraction followed by socket preservation surgery using one of two bone graft materials. Standard postoperative care is provided including antibiotics, pain medication, and oral rinses. Sutures are removed after 14 days.
1 surgical visit and 1 suture removal visit
Duration - 2 to 3 months
Participants return at 2 to 3 months post-surgery for CBCT scans to assess bone healing, followed by a surgical re-entry to obtain biopsies and place dental implants.
2 visits (CBCT scan and surgical re-entry)
Trial Site Locations
Total: 1 location
1
College of Dentistry, Pharos University
Alexandria, Egypt
Actively Recruiting
Research Team
H
Haitham Sakr, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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