Actively Recruiting
Comparative Analysis of Delirium in Older Adults Treated With Ceftazidime, Cefepime, or Ceftriaxone
Led by Alexandria University · Updated on 2025-06-18
120
Participants Needed
1
Research Sites
60 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to learn if the use of ceftazidime, cefepime, and ceftriaxone impacts the incidence of delirium in elderly patients (aged 65 and older) with infections. The main questions it aims to answer are: Does the administration of these antibiotics increase the incidence of delirium in elderly patients? How do renal and hepatic dose adjustments affect the likelihood of delirium? Researchers will observe elderly patients receiving either ceftazidime, cefepime, or ceftriaxone for infection management to see if these antibiotics contribute to the onset of delirium, and then assessing the severity of the delirium. Participants will: Be assessed for delirium using the CAM (Confusion Assessment Method) at 2, 4, and 6 days after starting treatment. Have their QSOFA (Quick Sequential Organ Failure Assessment) and NEWS (National Early Warning Score) tracked to evaluate their overall health status. Undergo dose adjustments based on renal and hepatic function as part of their treatment. Use the DRS.R89 score to assess delirium if it occurred.
CONDITIONS
Official Title
Comparative Analysis of Delirium in Older Adults Treated With Ceftazidime, Cefepime, or Ceftriaxone
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 65 years or older
- Hospitalized patients at Alexandria university hospitals diagnosed with infection
- Patients treated with ceftriaxone, ceftazidime, or cefepime
- No history of delirium before hospitalization
You will not qualify if you...
- Allergy or contraindication to cephalosporins
- Presence of septic shock
- Use of medications that may cause delirium such as anticholinergics, benzodiazepines, or opioid analgesics
- History of alcohol or drug abuse within the past year or current withdrawal
- Major surgery requiring general anesthesia within the last 30 days
- Severe electrolyte imbalances (hypernatremia, hyponatremia, hypercalcemia, or hypocalcemia)
- End-stage renal disease requiring dialysis
- Severe liver disease (e.g., Child-C)
- Severe uncontrolled pain affecting cognitive function
AI-Screening
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Trial Site Locations
Total: 1 location
1
Alexandria Main University Hospitals
Alexandria, Egypt, Egypt, 21519
Actively Recruiting
Research Team
R
Rana Kh Draz, Pharm D.
CONTACT
N
Noha A Hamdy, Ph.D
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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