Study Comparing Reflux Esophagitis in People With and Without Esophageal Motility Disorders Undergoing POEM Treatment

What this Trial Is About

Achalasia is a disorder affecting the movement of the esophagus and the relaxation of the lower esophageal sphincter, likely caused by nerve damage. This trial compares the features of reflux-related erosions after a treatment called per-oral endoscopic myotomy POEM with those in people who have reflux disease but no esophageal motility disorders. The study seeks to better understand the differences in esophagitis between these groups. Participants receiving POEM will be treated using a standardized method and given a single daily dose of an anti-secretory medication like esomeprazole for two months after the procedure. They will be followed for at least three months, during which proton pump inhibitors will be stopped for four weeks before assessment. Follow-up includes symptom questionnaires, endoscopy, and 24-hour pH monitoring to evaluate esophagitis and reflux characteristics. These findings will be compared with those from patients diagnosed with gastroesophageal reflux disease without motility disorders. During the study, participants will provide demographic and clinical data, and undergo pre- and post-treatment manometry. After three months, they will complete reflux symptom questionnaires and have an endoscopy and pH impedance test to measure esophageal acid exposure and observe esophagitis. Researchers will assess the size, type, and location of esophageal erosions to compare outcomes. The study spans from initial treatment through a six-month assessment period to monitor reflux and esophageal changes.

Comparative Assessment of Esophagitis in Cases With and Without Esophageal Motility Disorders: A Prospective Study