Actively Recruiting
Comparative Clinical and Biochemical Study Evaluating the Effectiveness of Metformin Versus Febuxostat on Gouty Obese Non-Diabetic Patients
Led by Mostafa Bahaa · Updated on 2025-06-24
60
Participants Needed
1
Research Sites
81 weeks
Total Duration
On this page
Sponsors
M
Mostafa Bahaa
Lead Sponsor
D
Dalia Naser Abdel-Sadek Safa , Faculty of Pharmacy, Tanta University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Gout is a systemic disease that results from the deposition of monosodium urate crystals (MSU) in tissues. Increased serum uric acid (SUA) above a specific threshold (\>6.8 mg/dl) is a requirement for the formation of uric acid crystals. MSU crystals can be deposited in all tissues mainly in and around the joints forming tophi. Early presentation of gout is an acute joint inflammation that is quickly relieved by non-steroidal anti-inflammatory drugs (NSAIDs) or colchicine. Lowering SUA levels below deposition threshold either by dietary modification or using serum uric acid lowering drugs is the main goal in management of gout. This results in dissolution of MSU crystals preventing further attacks
CONDITIONS
Official Title
Comparative Clinical and Biochemical Study Evaluating the Effectiveness of Metformin Versus Febuxostat on Gouty Obese Non-Diabetic Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 18 to 65 years
- Diagnosed with gout with serum uric acid less than 7 mg/dl
- Diagnosed with obesity having body mass index (BMI) of 30 kg/m2 or higher
You will not qualify if you...
- Presence of any type of diabetes mellitus
- Taking drugs that cause high uric acid such as anti-TB agents, low dose aspirin, chemotherapy, diuretics, immunosuppressants, fructose, lactate infusion, testosterone, or xylitol
- Non-obese patients with BMI under 30 kg/m2
- Pregnant or breastfeeding women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mostafa Bahaa
Damietta, New Damietta, Egypt, 34518
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here