Study Comparing Pain and Healing After Fractional Ablation Using DFG Laser Versus CO2 Laser on Upper Thighs

What This Trial Is About

Researchers are evaluating whether the Difference Frequency Generation DFG laser causes less pain and faster wound healing compared to the Carbon Dioxide CO2 laser in healthy adults. The study also examines how each laser affects blood vessel characteristics in the skin using Optical Coherence Tomography OCT imaging. This research involves 23 healthy participants aged 18 years and older of any gender and skin type. Participants will receive laser treatments using both the DFG and CO2 lasers applied to their upper thighs. During the study, photography and pain scores will be recorded, and OCT imaging will be used to assess changes in the skins blood vessels. The study focuses on low fluence fractional ablation, and all procedures occur over several study visits. Throughout the study, participants will have pain measured using the Visual Analog Scale at 90 minutes post-treatment and wound healing tracked over one month. Researchers will also evaluate vessel density, length, and thickness via OCT imaging. The total study duration allows for comprehensive monitoring of healing and vascular changes, ensuring detailed assessment of both laser treatments.

A Comparative Clinical Study to Assess Pain Score and Wound Healing Following Fractional Ablation With a DFG Laser and CO2 Laser