Comparative Diagnostic Yield of Endobronchial Cryo Biopsy vs Forceps Biopsy in Patients Undergoing Endobronchial Ultrasound Guided Transbronchial Needle Aspiration for Suspected Sarcoidosis

What this Trial Is About

Sarcoidosis is a disease that affects multiple organs, mainly the lungs and lymph nodes, causing granulomas or small clusters of immune cells. This research compares two methods of taking tissue samples from the airways in patients suspected of having sarcoidosis. The study aims to determine which biopsy method, cryo-endobronchial biopsy or forceps biopsy, provides better diagnostic information when combined with standard lymph node sampling. The study will enroll 150 patients suspected of pulmonary sarcoidosis, randomly assigning them to receive either cryo-endobronchial biopsy or forceps biopsy after routine endobronchial ultrasound-guided lymph node sampling. Each patient will have biopsies taken from specific airway locations regardless of visible abnormalities, with additional samples from abnormal areas if found. Tissue samples will be prepared and analyzed by a pathologist who will not know which biopsy method was used. Participants will undergo bronchoscopy and biopsy procedures, followed by laboratory tests to assess the quality and diagnostic value of the tissue samples. Researchers will measure the diagnostic yield of each biopsy method and the combined yield with lymph node sampling. Safety and any complications will also be tracked from enrollment until two weeks after the last patient is enrolled. The study will help determine the best way to obtain airway tissue samples for diagnosing sarcoidosis.

Comparative Diagnostic Yield of Endobronchial Cryo Biopsy vs Forceps Biopsy in Patients With Suspected Sarcoidosis