Actively Recruiting
A Comparative Split-Face Study of Long-Pulsed 1064-nm Nd:YAG and Fractional CO2 Laser for Skin Rejuvenation Based on Dermal Thickness, Skin Elasticity, Wrinkle Assessment, and Global Aesthetic Improvement Scale Scores
Led by Universitas Padjadjaran · Updated on 2026-03-12
15
Participants Needed
1
Research Sites
5 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Skin rejuvenation aims to improve the signs of skin aging, which involve changes in the skin's layers including reduced collagen leading to thinner skin, laxity, and wrinkles. This trial evaluates and compares two types of laser therapies, fractional CO₂ laser and long-pulsed 1064-nm Nd:YAG laser, both used to stimulate collagen production and improve skin condition. The goal is to assess their effects on dermal thickness, skin elasticity, wrinkles, and overall aesthetic improvement in adults aged 30 to 59 with moderate skin aging.
CONDITIONS
Brief Title
Comparative Effectiveness of Long-Pulsed 1064-nm Nd:YAG and Fractional CO₂ Laser in Skin Rejuvenation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female patients with skin aging classified as Glogau scale II-III
- Age between 30 and 59 years
You will not qualify if you...
- Pregnant or breastfeeding women
- Active smokers
- Individuals with high levels of sun exposure
- History of facial laser therapy, microdermabrasion, chemical peeling, botulinum toxin injection, microneedling, or skin booster injections within the past six months
- Use of oral isotretinoin within the past six months
- Use of topical retinoids or their derivatives, topical vitamin C, or other collagen-stimulating and skin-rejuvenating agents within the past two weeks
- Use of oral vitamin C, collagen-stimulating supplements, antioxidants, or hormone therapy with skin-rejuvenating effects within the past one month
- Presence of active facial skin inflammation
- History of keloid formation
- History of allergy to topical lidocaine anesthesia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 3 months
Participants receive split-face laser treatments: fractional CO₂ laser on one randomized side of the face and long-pulsed 1064-nm Nd:YAG laser on the other side. Treatments are performed three times at one-month intervals to improve skin rejuvenation.
3 treatment visits at one-month intervals
Trial Site Locations
Total: 1 location
1
Hasan Sadikin General Hospital
Bandung, West Java, Indonesia, 40161
Actively Recruiting
Research Team
A
Ahmad R Ganiem, M.D., Ph.D
K
Kartika Ruchiatan, M.D.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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