Actively Recruiting
LGBTQIA+ Initiative for Empowerment, Support, Coping, and PTSD Education: A Comparative Effectiveness Study of PTSD Treatments Among Sexual and Gender Minority Populations
Led by Stanford University · Updated on 2025-04-24
400
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
Sponsors
S
Stanford University
Lead Sponsor
P
Patient-Centered Outcomes Research Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of two PTSD treatments, Cognitive Processing Therapy (CPT) and STAIR Narrative Therapy (SNT), among adults who identify as part of the LGBTQIA+ community. The study aims to find out which treatment better reduces PTSD symptoms, improves quality of life, and lessens depression. It also explores how stress from stigma, discrimination, and drug or alcohol use may affect treatment outcomes, and whether these treatments work differently for various groups within the LGBTQIA+ population. Participants will be randomly assigned to receive either CPT, which involves about 12 sessions focusing on changing beliefs and processing emotions related to trauma, or SNT, a longer therapy with about 16 sessions including coping skills for emotional regulation and a trauma-focused narrative component. Treatments are delivered either in person or via videoconferencing. The study compares these two therapies to understand which is more effective for LGBTQIA+ adults with PTSD. During the study, participants will complete assessments at the start and at 3, 6, and 12 months to measure changes in PTSD symptoms, depression, quality of life, and satisfaction with therapy. Researchers will also track treatment completion rates. The total participation time covers these assessments and treatment sessions, with monitoring to understand how well participants respond and adhere to the therapies.
CONDITIONS
Brief Title
A Comparative Effectiveness Study of PTSD Treatments Among Sexual and Gender Minority Populations
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Currently live in California
- Ability to understand study procedures and comply with them for the entire study
- Ability to understand and willing to sign a written informed consent document
- Ability to speak and read English or Spanish
- Identify as a sexual and/or gender minority
- Score 33 or higher on the PTSD Checklist-5 (PCL-5)
- Interest in getting treatment for PTSD
- Not currently in another psychotherapy treatment for PTSD
- Able to attend treatment sessions in person in San Francisco or access treatment via videoconferencing
You will not qualify if you...
- Contraindication to any study-related procedure or assessment
- Clinically significant impairment interfering with full participation (including symptoms of schizophrenia, schizoaffective disorder, bipolar disorder, or other disorders)
- Active suicidal intent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or via videoconferencing)
Duration - Approximately 12 to 16 weekly sessions
Participants receive one of two PTSD treatments: Cognitive Processing Therapy or STAIR Narrative Therapy, which involve sessions focused on trauma processing and coping skills.
Weekly therapy sessions for 12 to 16 weeks
Duration - Up to 12 months after treatment begins
Participants are monitored for changes in PTSD symptoms, depression, quality of life, and satisfaction with therapy after completing treatment.
Assessments at 3, 6, and 12 months post-baseline
Trial Site Locations
Total: 2 locations
1
Stanford University
Palo Alto, California, United States, 94304
Actively Recruiting
2
UCSF Alliance Health Project
San Francisco, California, United States, 94103
Actively Recruiting
Research Team
A
Annesa P Flentje, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here