Actively Recruiting
Comparative Effectiveness Study of Two Forms of Ketamine for Treatment-resistant Depression
Led by The George Institute · Updated on 2025-06-03
162
Participants Needed
6
Research Sites
147 weeks
Total Duration
On this page
Sponsors
T
The George Institute
Lead Sponsor
T
The University of New South Wales
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to compare the effectiveness of two formulations of ketamine - Spravato® and racemic ketamine - in people with treatment-resistant depression (TRD). The main questions it aims to answer are: * How the two formulations compare in terms of their effectiveness in treating TRD. * How the two formulations compare in their acceptability to patients, safety, effects on patient quality of life and function, and cost effectiveness. Participants will be randomised to receive either Spravato® or racemic ketamine treatment and asked to complete some questionnaires to assess the effects on mood, treatment acceptability, side effects, quality of life and function, and health economic outcomes.
CONDITIONS
Official Title
Comparative Effectiveness Study of Two Forms of Ketamine for Treatment-resistant Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult with treatment-resistant depression who has a current depressive episode
- Assessed by clinic psychiatrist as appropriate for racemic ketamine or Spravato4 treatment
- Aged 18 years or older
- Provided written informed consent for research study
You will not qualify if you...
- Unable to give informed consent
- Any physical or mental condition that could interfere with study participation or assessments
- Requires an interpreter for clinic consent process, making research assessments infeasible
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Royal Prince Alfred Hospital
Camperdown, New South Wales, Australia, 2050
Actively Recruiting
2
Black Dog Institute
Randwick, New South Wales, Australia, 2031
Actively Recruiting
3
Ramsay Clinic Northside
St Leonards, New South Wales, Australia, 2065
Actively Recruiting
4
Ramsay Clinic Lakeside
Warners Bay, New South Wales, Australia, 2282
Actively Recruiting
5
Gold Coast University Hospital
Southport, Queensland, Australia, 4215
Actively Recruiting
6
Ramsay Clinic Albert Road
Melbourne, Victoria, Australia, 3004
Actively Recruiting
Research Team
A
Abigail Hansen
CONTACT
F
Fay Wang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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