Actively Recruiting
Comparative Efficacy of Pregabalin and Lacosamide in Patients With Herpes Zoster and Post Herpetic Neuralgia
Led by CMH Kharian Medical College · Updated on 2025-05-14
50
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Post-herpetic neuralgia (PHN) is a painful complication that can occur after herpes zoster, caused by reactivation of the Varicella-Zoster virus. PHN leads to chronic nerve pain that may interfere with sleep and daily activities, especially affecting older adults and those with weakened immune systems. This research aims to compare two drugs, Pregabalin and Lacosamide, to see how they work in treating PHN, as there are few studies directly comparing these treatments for this condition. Participants will be randomly assigned to one of two groups: Group A will take Pregabalin capsules (150 mg once daily) for 4 weeks, and Group B will take Lacosamide tablets (100 mg twice daily) for the same duration. Both medications are given orally, and the study will monitor the effects of these treatments over the 4-week period. During the study, participants’ pain levels will be measured using the Visual Analog Scale at 4 weeks to assess treatment effectiveness. Researchers will monitor participants throughout the trial, which starts in April 2025 and ends in September 2025. The trial involves adults aged 18 to 50 diagnosed with PHN following herpes zoster. Safety and treatment outcomes will be observed during this time.
CONDITIONS
Brief Title
Comparative Efficacy of Pregabalin and Lacosamide in Patients With Herpes Zoster and Post Herpetic Neuralgia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed cases of herpes zoster suffering from postherpetic neuralgia
- Ages: 18 to 50
- Both male and female
You will not qualify if you...
- Lack of consent
- Patient already taking pain killers for post herpetic neuralgia
- Patients suffering from other systemic illness
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 4 weeks
Participants receive either Pregabalin or Lacosamide to treat postherpetic neuralgia.
Weekly visits for 4 weeks
Trial Site Locations
Total: 1 location
1
CMH Kharian Medical College
Kharan, Punjab Province, Pakistan, 50070
Actively Recruiting
Research Team
M
Mushayada Irshad, MBBS, MPhil Pharmacology
M
Muhammad Waseem Shahid, MBBS, FCPS Dermatology
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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