Actively Recruiting
Comparative Efficacy of Rivaroxaban and Enoxaparin in Post-Laparotomy DVT Prevention
Led by Mayo Hospital Lahore · Updated on 2025-11-21
212
Participants Needed
1
Research Sites
5 weeks
Total Duration
On this page
Sponsors
M
Mayo Hospital Lahore
Lead Sponsor
K
King Edward Medical University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if rivaroxaban works better than enoxaparin to prevent deep vein thrombosis (DVT) after emergency exploratory laparotomy in adults. It will also learn about the safety of rivaroxaban compared to enoxaparin. The main questions it aims to answer are: Does rivaroxaban lower the number of patients who develop DVT after exploratory laparotomy compared to enoxaparin? What medical problems or side effects do participants have when taking rivaroxaban versus enoxaparin? Researchers will compare rivaroxaban (an oral anticoagulant) to enoxaparin (a subcutaneous injection) to see which drug works better to prevent blood clots after surgery. Participants will: Take rivaroxaban 10 mg orally once daily for 7 days, or enoxaparin 40 mg subcutaneously once daily for 7 days after surgery Undergo duplex color Doppler ultrasound scans of the legs on day 5 and day 10 after surgery Be monitored for bleeding, complications, and other side effects
CONDITIONS
Official Title
Comparative Efficacy of Rivaroxaban and Enoxaparin in Post-Laparotomy DVT Prevention
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 to 80 years
- Both male or female patients
- Patients who have undergone emergent exploratory laparotomy for any reason whether traumatic or non-traumatic
- Patients with expected immobility for more than 24 hours
You will not qualify if you...
- Patients with diagnosed pre-operative deep vein thrombosis
- Body mass index (BMI) over 40
- Patients on mechanical ventilation postoperatively
- Patients with postoperative myocardial infarction, ischemic heart disease, or cerebrovascular accident
- Patients who have had limb surgery in addition to exploratory laparotomy
AI-Screening
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Trial Site Locations
Total: 1 location
1
Mayo Hospital Lahore
Lahore, Punjab Province, Pakistan, 54570
Actively Recruiting
Research Team
M
Muhammad Mashhood Shad, FCPS
CONTACT
S
Shahroze Wajid, FCPS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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