Actively Recruiting
''Comparative Evaluation of Change in Bite Force and Levels of Bone Turnover Markers CTX and BALP in Hyperdivergent and Hypodivergent Cases During Retention Phases-A Prospective Clinical Trial ''
Led by Postgraduate Institute of Dental Sciences Rohtak · Updated on 2024-12-10
40
Participants Needed
1
Research Sites
83 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Long-term studies have shown that various occlusal changes occur after the active phase of orthodontic treatment. some of these changes are unwanted changes and are considered as relapse The retention appliances are used to maintain the arch dimensions and alignment of the teeth after completion of the orthodontic treatment. One indicator of the functional state and health of the masticatory system is maximum voluntary bite force (MVBF). Its values vary in accordance to the location of measurement (highest at the first molar, lower at the incisors). People with pronounced horizontal craniofacial growth have somewhat higher values of MVBF, and those with vertical growth have lower values than do those with an average growth pattern. Clinical case reports and descriptive histologic data exist suggesting that bone and tooth remodeling persist for extended periods after removal of appliance or deactivation. A reflection of bone remodelling can be found in the gingival crevicular fluid (GCF) of moving teeth, with decrease or increase in the concentration of biomarker. This prompted us to evaluate the expression of variation in bone turnover marker levels (CTX-Bone resorption marker and BALP -Bone formation marker ) during the retention period. The International Osteoporosis Foundation (IOF) and International Federation of Clinical Chemistry (IFCC) have recommended C-terminal telopeptide of type I collagen (CTX) as one of the reference for BTMs. Hence, The present trial will be undertaken to assess the changes and compare if there is any difference in bite force and change in level of bone biomarker biomarker CTX type 1 collagen(C-terminal telopeptide of type I collagen and bone specific alkaline phosphatase(BALP) in post orthodontic treatment hypodivergent and hyperdivergent cases using beggs retainer over 12 months of period of retention.
CONDITIONS
Official Title
''Comparative Evaluation of Change in Bite Force and Levels of Bone Turnover Markers CTX and BALP in Hyperdivergent and Hypodivergent Cases During Retention Phases-A Prospective Clinical Trial ''
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 to 25 years who have completed fixed orthodontic treatment and are ready for debonding
- Patients with vertical growth pattern (FMA of 26 or more) for hyperdivergent cases
- Patients with horizontal growth pattern (FMA of 24 or less) for hypodivergent cases
- Optimal functional bite at end of treatment (PAR score > 70%)
- Little's irregularity index less than 6mm in both upper and lower teeth before treatment
- Patients without surgery or orthopedic treatment and no syndromes
- Good gum health and oral hygiene (probing depth less than 3mm, gingival index score less than 1)
- Good compliance with wearing retainers
You will not qualify if you...
- Patients with incomplete orthodontic treatment
- Patients with temporomandibular joint (TMJ) disorders
- Patients with systemic diseases affecting bone or growth
- Patients with incomplete medical records
- Patients who do not follow up or complete treatment
- Patients with learning difficulties
- Patients who had antibiotic therapy within 3 months or anti-inflammatory drugs within 1 month before the study
AI-Screening
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Trial Site Locations
Total: 1 location
1
Dr Rekha
Rohtak, Haryana, India, 124001
Actively Recruiting
Research Team
D
Dr manisha kukreja, MDS
CONTACT
D
Dr Aaliya khan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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