What is this study trying to find out about bite force and bone markers after orthodontic treatment?

This study aims to evaluate changes in bite force and levels of bone turnover markers CTX and BALP during the retention phase after orthodontic treatment. Researchers want to understand differences between patients with vertical and horizontal facial growth patterns. The study is sponsored by the Postgraduate Institute of Dental Sciences Rohtak and helps improve knowledge about maintaining teeth alignment after braces.

Who may be eligible for this clinical trial about bite force and bone markers?

Adults aged 18 to 45 years who have completed fixed orthodontic treatment and are ready for retainer delivery may be eligible. Participants should have either a vertical or horizontal facial growth pattern and good oral hygiene. People with systemic diseases affecting bone, TMJ disorders, or recent antibiotic or anti-inflammatory use are excluded. Please review eligibility criteria for more details.

Is there any cost to participate in this clinical trial?

Study-related care, including the retainer and all trial visits, is provided at no cost. Personal travel expenses may vary and are not guaranteed to be covered. Participants can expect regular visits over a 12-month period for assessments and sample collection.

Actively Recruiting

Phase Not Applicable

Age: 18Years - 45Years

All Genders

Healthy Volunteers

ID06456827

Comparative Evaluation of Change in Bite Force and Levels of Bone Turnover Markers CTX and BALP in Hyperdivergent and Hypodivergent Cases During Retention Phases - A Prospective Clinical Trial

Led by Postgraduate Institute of Dental Sciences Rohtak · Updated on 2024-12-10

Participants Needed

Research Sites

34 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are studying how bite force and bone turnover markers change during the retention phase after orthodontic treatment in patients with different vertical facial growth patterns. The study compares patients with vertical hyperdivergent and horizontal hypodivergent craniofacial growth to understand relapse and bone remodeling processes over a 12-month retention period. This prospective clinical trial aims to provide insights into maintaining teeth alignment using retention appliances after fixed orthodontic treatment. The trial includes two groups of patients who have completed fixed orthodontic treatment and are ready for retainer delivery. Group 1 consists of patients with vertical growth patterns FMA 26 or more, while Group 2 includes those with horizontal growth patterns FMA 24 or less. Both groups will receive a Beggs retainer formed conventionally and delivered within 24 hours of debonding. Changes in bite force will be measured using a bite force device, and bone turnover markers CTX bone resorption and BALP bone formation will be assessed using ELISA at baseline and at 1, 3, 6, and 12 months after retainer delivery. Participants will undergo bite force measurements and biomarker testing at five timepoints during the 12 months retention phase at retainer delivery, then after 1, 3, 6, and 12 months. Data on bone turnover markers and bite force changes will be collected and compared between the two groups. The study includes monitoring of functional occlusion, oral hygiene, and retainer compliance. The total participation time spans 12 months, during which researchers will assess both clinical and biochemical indicators of bone remodeling and bite function after orthodontic treatment.

CONDITIONS

Brief Title

''Comparative Evaluation of Change in Bite Force and Levels of Bone Turnover Markers CTX and BALP in Hyperdivergent and Hypodivergent Cases During Retention Phases-A Prospective Clinical Trial ''

Who Can Participate

Age: 18Years - 45Years

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Adults aged 18 to 25 years who have completed fixed orthodontic treatment and are ready for retainer delivery
Patients with vertical growth pattern (FMA of 26° or more) or horizontal growth pattern (FMA of 24° or less)
Optimal functional occlusion at end of treatment (PAR score >70%)
Little's irregularity index less than 6 mm in both upper and lower arch before treatment
Non-surgical, non-orthopedic, and non-syndromic patients
Good periodontal health and oral hygiene (probing depth less than 3 mm, gingival index score less than 1)
Good compliance with retainer wear

You will not qualify if you...

Incomplete orthodontic treatment
Temporomandibular joint (TMJ) disorders
Systemic diseases affecting bone and general growth
Incomplete patient records
Failure to follow up or complete treatment
Learning difficulties
Antibiotic therapy within the previous 3 months or anti-inflammatory drug use in the month before the study

Research Team

Dr manisha kukreja, MDS

Dr Aaliya khan

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