Actively Recruiting
Comparative Evaluation of the Performance of Different Thromboplastin Reagents on Prothrombin Time and Factorial Assays in Situations of Isolated Extrinsic Pathway Factor Deficiency or Liver Damage.
Led by University Hospital, Strasbourg, France · Updated on 2025-08-08
100
Participants Needed
1
Research Sites
50 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Primary purpose : Compare the sensitivity of several thromboplastin reagents of various origins to prothrombin time and factor II, V, VII and X assays in two different populations of patients : * Patients with an isolated extrinsic pathway deficiency (acquired or congenital) of factor II or V or VII or X. * Patients with an hepatocellular insufficiency generally associated with coagulopathy (with an intensity proportional to the degree of hepatic impairment). Results of this work should improve knowledge of sensitivity of the screening test represented by the prothrombin time, depending on the origin of thromboplastin reagent used, in relation with coagulopathies mentioned above, as well as the performance of factors II, V, VII, X assays. This work would help to choice of the most suitable reagent for the needs of each hemostasis laboratory/center.
CONDITIONS
Official Title
Comparative Evaluation of the Performance of Different Thromboplastin Reagents on Prothrombin Time and Factorial Assays in Situations of Isolated Extrinsic Pathway Factor Deficiency or Liver Damage.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Plasma samples must come from patients tested at Strasbourg University Hospital and be anonymized after routine testing.
- Patients must have an isolated or combined deficiency of extrinsic pathway factors II, V, VII, or X.
You will not qualify if you...
- Patients currently treated with oral anticoagulant medications.
- Patients currently treated with parenteral anticoagulant medications, except therapeutic doses of unfractionated heparin or low molecular weight heparin.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Hôpitaux Universitaires de Strasbourg - Laboratoire de Virologie
Strasbourg, France, 67091
Actively Recruiting
Research Team
J
Jordan Laurent WIMMER
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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