Actively Recruiting
Comparative Evaluation of Preoperative Preparation Methods in Patients With Large Incisional Hernias
Led by State Budget Public Health Institution Scientific Research Institute - Ochapovsky Regional Clinical Hospital · Updated on 2026-04-23
120
Participants Needed
1
Research Sites
213 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients with large, complex, or giant incisional hernias often require advanced preoperative optimization to facilitate safe abdominal wall reconstruction and reduce postoperative complications. Several strategies are currently used in clinical practice, including botulinum toxin A injection, progressive preoperative pneumoperitoneum, and their combination. However, the optimal differentiated approach based on hernia characteristics and abdominal wall tissue deficiency remains unclear. This study aims to compare the effectiveness and safety of different preoperative preparation strategies in patients with large postoperative ventral hernias and loss of abdominal wall domain. Outcomes of patients receiving botulinum toxin A, progressive preoperative pneumoperitoneum, combined preparation, or no specific preparation will be analyzed. The study will evaluate operative feasibility, ability to achieve fascial closure, postoperative complications, recurrence, and overall treatment outcomes.
CONDITIONS
Official Title
Comparative Evaluation of Preoperative Preparation Methods in Patients With Large Incisional Hernias
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Patients with ventral incisional hernia requiring elective surgical repair
- Large and/or complex hernia defects requiring preoperative preparation
- Ability to provide informed consent
You will not qualify if you...
- Age under 18 years
- Emergency surgery
- Pregnancy
- Contraindications to botulinum toxin A injection or progressive pneumoperitoneum
- Severe uncontrolled comorbidities precluding surgery
- Inability or refusal to provide informed consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
Ochapovsky Regional Clinical Hospital No.1
Krasnodar, Krasnodarskiy Kray, Russia, 350000
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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