Actively Recruiting
Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine
Led by University of California, San Francisco · Updated on 2026-05-14
18
Participants Needed
1
Research Sites
125 weeks
Total Duration
On this page
Sponsors
U
University of California, San Francisco
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administration, and participants' feelings of craving/withdrawal and enjoyment.
CONDITIONS
Official Title
Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy based on medical history and physical exam
- Current regular user of electronic cigarettes at least 15 days in the past 30 days
- Age between 21 and 65 years
You will not qualify if you...
- Use of medications that induce nicotine metabolizing enzyme CYP2A6 (e.g., rifampicin, carbamazepine, phenobarbital)
- Use of sympatholytic medications for cardiovascular conditions (e.g., beta or alpha-blockers)
- Use of nicotine-containing medications (e.g., patch, lozenge, gum)
- Use of stimulant medications generally given for ADHD treatment (e.g., Adderall)
- Pregnancy or breastfeeding
- Women of childbearing potential not using acceptable contraception
- Unable to read and write in English
- Known allergy to propylene glycol or vegetable glycerin
- Uncomfortable with blood draws
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Zuckerberg San Francisco General Hospital (ZSFG)
San Francisco, California, United States, 94110
Actively Recruiting
Research Team
L
Lisa Lawrence
CONTACT
A
Armando Barraza
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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