Actively Recruiting

Age: 50Years - 80Years
All Genders
Healthy Volunteers
ID06900270

Cross-sectional Cohort Analysis of Plasma Proteomics and Metabolomics in Coronary Artery Disease: Comparison of Patients with Obstructive (≥ 50%), Non-obstructive (< 50%), and No Lesions

Led by University of Sao Paulo General Hospital · Updated on 2025-03-28

66

Participants Needed

1

Research Sites

30 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are investigating the differences in plasma proteomic and metabolomic profiles among individuals with varying degrees of coronary artery disease (CAD), including those without lesions, those with non-obstructive lesions less than 50%, and those with obstructive lesions of 50% or more. The study aims to find specific biomarkers that relate to CAD progression and clinical events, improving understanding and potentially guiding personalized treatment decisions. This cross-sectional cohort study involves 66 patients categorized into three groups based on coronary computed tomography angiography (CCTA) or invasive coronary angiography (ICA) results. Participants will have a single study visit during which demographic and clinical data will be collected, and blood samples drawn for biochemical, proteomic, and metabolomic analyses. Blood samples will be processed and analyzed at specialized laboratories using techniques such as liquid chromatography-mass spectrometry (LC-MS) to identify and quantify proteins and metabolites related to CAD. The proteomic profiles will be compared across the three groups to identify differentially expressed proteins and potential biomarkers associated with disease severity. During the visit, participants will undergo assessments including blood pressure, heart rate, weight, and height measurements. Blood tests will measure various biochemical parameters such as blood glucose, cholesterol levels, inflammatory markers, and liver and kidney function tests. Researchers will analyze the collected data to correlate proteomic findings with clinical events and laboratory results. Participant data confidentiality is ensured through coding and restricted access, and the study will assess protein differences over one year to help understand CAD progression and prognosis.

CONDITIONS

Brief Title

Comparative of Plasma Proteomics & Metabolomics in Coronary Artery Disease: Obstructive,Non-Obstructive, & No Lesions

Who Can Participate

Age: 50Years - 80Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients without manifest atherosclerotic disease, including no history of angina, myocardial infarction, revascularization, cerebrovascular disease, or peripheral vascular disease
  • Patients with non-obstructive coronary lesions (< 50%) detected by CCTA or ICA
  • Patients with obstructive coronary lesions (≥ 50%) detected by CCTA or ICA
  • Age between 50 and 80 years
  • Ability and willingness to provide informed consent
Not Eligible

You will not qualify if you...

  • Refusal to sign the informed consent form
  • Presence of non-atherosclerotic heart diseases such as valvular diseases, cardiomyopathies, or congenital heart diseases
  • Severe nephropathy with creatinine clearance less than 30 mL/min/1.73 m²
  • Malignant neoplasms or other chronic diseases with poor prognosis
  • Acute coronary syndromes within the last 90 days
  • Active smoking

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Single visit

Participants undergo blood collection and demographic data assessment during a single visit to provide samples for proteomic and metabolomic analysis.

1 visit (in-person)

Long-term Monitoring

Duration - 1 year

Participants' plasma proteomic and metabolomic profiles are analyzed and correlated with clinical events and biochemical parameters over 1 year to identify potential biomarkers and disease progression.

No additional visits; monitoring is based on laboratory data and records

Trial Site Locations

Total: 1 location

1

Instituto do Coração InCor, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo

São Paulo, São Paulo, Brazil, 05403-000

Actively Recruiting

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Research Team

V

Vinícius Quintão MD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

3

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Frequently Asked Questions

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Published Research Related To This Trial

Spectral binning as an approach to post-acquisition processing of high resolution FIE-MS metabolome fingerprinting data.

Jasen P Finch, Thomas Wilson, Laura Lyons...

https://pubmed.ncbi.nlm.nih.gov/35917032

Within-day reproducibility of an HPLC-MS-based method for metabonomic analysis: application to human urine.

Helen G Gika, Georgios A Theodoridis, Julia E Wingate...

https://pubmed.ncbi.nlm.nih.gov/17625818

Metabolic disturbances identified in plasma are associated with outcomes in patients with heart failure: diagnostic and prognostic value of metabolomics.

Mei-Ling Cheng, Chao-Hung Wang, Ming-Shi Shiao...

https://pubmed.ncbi.nlm.nih.gov/25881932