Study Comparing Blood Protein and Metabolite Profiles in Coronary Artery Disease Among Patients With Obstructive, Non-Obstructive, and No Coronary Lesions

What this Trial Is About

Researchers are investigating the differences in plasma proteomic and metabolomic profiles among individuals with varying degrees of coronary artery disease CAD, including those without lesions, those with non-obstructive lesions less than 50%, and those with obstructive lesions of 50% or more. The study aims to find specific biomarkers that relate to CAD progression and clinical events, improving understanding and potentially guiding personalized treatment decisions. This cross-sectional cohort study involves 66 patients categorized into three groups based on coronary computed tomography angiography CCTA or invasive coronary angiography ICA results. Participants will have a single study visit during which demographic and clinical data will be collected, and blood samples drawn for biochemical, proteomic, and metabolomic analyses. Blood samples will be processed and analyzed at specialized laboratories using techniques such as liquid chromatography-mass spectrometry LC-MS to identify and quantify proteins and metabolites related to CAD. The proteomic profiles will be compared across the three groups to identify differentially expressed proteins and potential biomarkers associated with disease severity. During the visit, participants will undergo assessments including blood pressure, heart rate, weight, and height measurements. Blood tests will measure various biochemical parameters such as blood glucose, cholesterol levels, inflammatory markers, and liver and kidney function tests. Researchers will analyze the collected data to correlate proteomic findings with clinical events and laboratory results. Participant data confidentiality is ensured through coding and restricted access, and the study will assess protein differences over one year to help understand CAD progression and prognosis.

Comparative of Plasma Proteomics & Metabolomics in Coronary Artery Disease: Obstructive,Non-Obstructive, & No Lesions