Study Comparing Intravenous Hydrocortisone and Dexmedetomidine to Prevent Shivering After Abdominal Surgery with General Anesthesia

What this Trial Is About

Researchers are evaluating the effectiveness of two intravenous drugs, hydrocortisone and dexmedetomidine, in preventing and treating shivering after general anesthesia in patients undergoing abdominal surgeries. This is a randomized controlled clinical trial conducted at Ain Shams University hospitals, focused on adult patients aged 18 to 65 years who are undergoing abdominal open surgeries lasting up to 120 minutes. The study aims to compare these drugs ability to reduce postoperative shivering and monitor hemodynamic changes. Participants are randomly assigned to one of two groups Group A receives hydrocortisone at a dose of 2 mgkg, and Group B receives dexmedetomidine at 1 microgramkg. Both drugs are administered intravenously about 30 minutes before the anticipated end of surgery. Standard anesthesia protocols, including induction and maintenance, are followed, with monitoring of vital signs and core temperature throughout the procedure. After surgery, patients are extubated and transferred to the post-anesthesia care unit for observation. During the study, participants undergo regular monitoring of core temperature and vital signs at specific intervals. Shivering is assessed using a validated scale from 0 no shivering to 3 severe whole-body shivering during the 30 minutes after surgery while in the recovery area. The primary outcome is the number of patients who experience shivering in response to decreased body temperature. Secondary outcomes include observing any changes in heart rate and blood pressure. The total participation includes preoperative assessment, intraoperative treatment, and 30 minutes of postoperative monitoring.

Comparative Study Between the Efficacy of Intravenous Hydrocortisone and Intravenous Dexmedetomidine for Prevention of Postoperative Shivering After General Anaesthesia for Abdominal Surgeries