Study Comparing 2% Calcium Hypophosphite Toothpaste to Sodium Fluoride Toothpaste 1450 ppm F for Preventing Tooth Decay in Adults Aged 18 to 45

What this Trial Is About

Researchers are comparing the caries-preventive effects of two toothpastes in adults aged 18 to 45. The study aims to show that a toothpaste containing 2% Calcium Hypophosphite is not worse than a standard Sodium Fluoride toothpaste 1450 ppm fluoride in preventing dental caries. The trial is sponsored by Dr. Joachim Enax and involves healthy volunteers. Participants will be randomly assigned to use either the 2% Calcium Hypophosphite toothpaste or the Sodium Fluoride toothpaste. Both groups will receive oral hygiene instructions and will apply their assigned toothpaste twice daily at home for 18 months 546 days. This is a quadruple-masked study to ensure unbiased results. During the study, participants will have evaluations including oral examinations by intraoral camera DIAGNOcam, bitewing radiographs, and assessments of dental plaque using the Plaque Control Record index. The main outcome measured is the Decay-Missing-Filled index at multiple time points up to 546 days. Secondary outcomes include prevention of interproximal caries lesions and dental plaque accumulation. Participants will be monitored throughout the 18-month period.

Comparative Study of Caries-Preventive Effects: 2% Calcium Hypophosphite Toothpaste vs. Sodium Fluoride Toothpaste (1450ppm F)