Actively Recruiting
Comparative Study of Caries-Preventive Effects: 2% Calcium Hypophosphite Toothpaste vs. Sodium Fluoride Toothpaste (1450ppm F)
Led by Dr. Joachim Enax · Updated on 2026-04-13
164
Participants Needed
2
Research Sites
101 weeks
Total Duration
On this page
Sponsors
D
Dr. Joachim Enax
Lead Sponsor
D
Department of Integrated Dentistry Medical University of Białystok
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of the study is to compare the caries-preventive effect of the test and control toothpaste in order to proof the non-inferiority of the test toothpaste compared to the control.
CONDITIONS
Official Title
Comparative Study of Caries-Preventive Effects: 2% Calcium Hypophosphite Toothpaste vs. Sodium Fluoride Toothpaste (1450ppm F)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- A minimum of 10 healthy molars and premolars (DMFS of these teeth = 0)
- Willingness to use an electric (powered) toothbrush
- Willingness to use interdental floss
- Willingness to have bitewing radiographs taken
- Willingness to undergo an oral examination by an intraoral camera (DIAGNOcam)
You will not qualify if you...
- Untreated caries detected by intraoral camera (DIAGNOcam); patients with one or two untreated caries can become eligible after restorative therapy, but those with three or more untreated caries will be excluded
- Xerostomia caused by medication, radiation, or disease
- Undergoing chemo or radiation therapy
- Physical or mental disability preventing proper oral health care
- Orthodontic treatment
- Severe periodontitis at baseline (pocket depth on any tooth ≥ 5.5 mm)
- Known allergy to ingredients in the tested toothpastes
- Regular medication affecting salivary function or flow
- Current pregnancy, planning pregnancy, suspicion of pregnancy, breastfeeding, or becoming pregnant during the study
- Having 3 or more carious lesions or restorations in the last 36 months before baseline
- Teeth lost due to caries in the last 36 months before baseline
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Department of Integrated Dentistry Medical University of Białystok
Bialystok, Poland, Poland, 15-276
Not Yet Recruiting
2
Poznan University of Medical Sciences, Department of Integrated Dentistry
Poznan, Poland, Poland, 60-812
Actively Recruiting
Research Team
J
Joachim Enax, PhD
CONTACT
C
Clarissa Masur, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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