Arthroscopic reconstruction of the anterior cruciate ligament. A comparison of patellar tendon autograft and four-strand hamstring tendon autograft.
I S Corry, J M Webb, A J Clingeleffer...
https://pubmed.ncbi.nlm.nih.gov/10424213Actively Recruiting
Phase Not Applicable
Age: 18Years +
All Genders
ID07346326
Comparative Study of Functional Outcomes Between Peroneus Longus and Hamstring Tendon Autografts in Arthroscopic ACL Reconstruction: A Randomized Controlled Trial
Led by Khyber Medical University Peshawar · Updated on 2026-01-16
64
Participants Needed
1
Research Sites
7 weeks
Total Duration
On this page
Sponsors
K
Khyber Medical University Peshawar
Lead Sponsor
K
Khyber Medical College, Peshawar
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating two types of tendon grafts for anterior cruciate ligament (ACL) reconstruction in patients aged 18 years and older with isolated ACL injuries. This prospective, single-blinded, randomized controlled trial aims to compare early functional outcomes using the Lysholm Knee Score at 6 weeks and 3 months after surgery. The goal is to determine if the peroneus longus tendon (PLT) graft is not inferior to the commonly used hamstring tendon (HST) graft. The study is conducted at a single center with ethical approval and informed consent from participants. Participants will be randomly assigned to receive ACL reconstruction using either the hamstring tendon autograft or the peroneus longus tendon autograft. Both procedures involve arthroscopic surgery under spinal anesthesia, with graft fixation using an Endobutton on the femoral side and an adjustable button system on the tibial side following a standard single-bundle technique. The PLT graft is harvested through a small incision near the ankle with a tenodesis of the peroneus brevis performed at the donor site. All patients will follow a standardized rehabilitation protocol after surgery. Throughout the study, participants will undergo assessments of knee instability and knee function at 6 weeks and 3 months post-surgery using validated scoring tools. The outcome assessor will be blinded to the treatment groups to ensure unbiased evaluation. The research team will monitor functional recovery and record any complications. The total study duration includes the surgical intervention and follow-up visits to collect data on early functional outcomes.
CONDITIONS
Brief Title
Comparative Study of Functional Outcomes Between Peroneus Longus and Hamstring Tendon Autografts in Arthroscopic ACL Reconstruction
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Patients aged 18 years or older
- Isolated, primary anterior cruciate ligament (ACL) injury confirmed by clinical assessment and MRI
- Written informed consent for surgery and study participation including follow-up assessments
You will not qualify if you...
- Multiligament knee injuries such as PCL, MCL, or LCL injuries
- Previous surgery or fracture in the involved lower limb
- Radiographic evidence of osteoarthritis in the affected knee
- Presence of any neuromuscular disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Day of surgery and immediate recovery period
Participants undergo arthroscopic anterior cruciate ligament (ACL) reconstruction using either a hamstring tendon or peroneus longus tendon autograft, followed by standard surgical recovery.
1 surgery visit (in-person)
Post-operative Follow-up
Duration - 3 months after surgery
Participants are assessed for knee instability and function at scheduled follow-up visits after surgery.
2 visits (at 6 weeks and 3 months, in-person)
Trial Site Locations
Total: 1 location
1
Khyber Teaching Hospital
Peshawar, KPK, Pakistan, 25100
Actively Recruiting
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Research Team
D
Dr Syed Dil Bagh Ali Shah, MBBS
D
Dr Syed Muhammad Shabbir Ali Naqvi, MSPT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
Harvesting hamstring tendons for ACL reconstruction influences postoperative hamstring muscle performance.
Nobuo Adachi, Mitsuo Ochi, Yuji Uchio...
https://pubmed.ncbi.nlm.nih.gov/12920536Peroneus longus autograft can be recommended as a superior graft to hamstring tendon in single-bundle ACL reconstruction.
Sholahuddin Rhatomy, Asa Ibrahim Zainal Asikin, Anggun E Wardani...
https://pubmed.ncbi.nlm.nih.gov/30877316Peroneus longus tendon autograft has functional outcomes comparable to hamstring tendon autograft for anterior cruciate ligament reconstruction: a systematic review and meta-analysis.
Jinshen He, Qi Tang, Sara Ernst...
https://pubmed.ncbi.nlm.nih.gov/32984919Randomized Controlled Study Comparing Hamstring Graft and Peroneus Longus Tendon Graft in Arthroscopic ACL Reconstruction.
Naiyer Asif, Mohammad Jesan Khan, Ujjawal Singhal...
https://pubmed.ncbi.nlm.nih.gov/39524299