What is GSK5784283 studying for asthma?

GSK5784283 is being studied to understand how two different forms of the medicine move through the body in healthy adults. The study aims to compare blood levels of the drug to see if the formulations behave similarly. This research is sponsored by GlaxoSmithKline and focuses on safety and how the body processes the medication.

Who may be eligible for this asthma clinical trial?

Adults aged 18 to 60 years who are healthy and meet weight and body mass index requirements may be eligible. Female participants must be of non-childbearing potential. People who smoke or have certain medical conditions may not qualify. Please review eligibility criteria for more details.

Is there any cost to participate in this asthma clinical trial?

Study-related care, including the study drug and all trial visits, is provided at no cost. Personal travel expenses may vary and are not guaranteed to be covered.

Actively Recruiting

Phase 1

Age: 18Years - 60Years

All Genders

Healthy Volunteers

ID07712393

Phase 1 Randomized Study Comparing Pharmacokinetics of Two GSK5784283 Formulations in Healthy Adults by Injection

Led by GlaxoSmithKline · Updated on 2026-07-29

Participants Needed

Research Sites

1 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are comparing how two different forms of the study medicine GSK5784283 are processed in the bodies of healthy adults. This phase 1 study aims to understand the pharmacokinetics of GSK5784283, evaluating its safety, how well it is tolerated, and whether the two formulations behave similarly in the body. Participants will receive one of two versions of GSK5784283 by injection. The study is randomized and parallel in design, meaning participants are assigned to either the test or reference formulation without switching. The research includes monitoring blood levels of the drug over time to assess concentration and exposure. Participants will be involved in regular monitoring up to 253 days after dosing. This includes blood tests to measure drug levels, assessments for side effects or adverse events, laboratory tests, vital signs, and heart monitoring using ECGs. Researchers will also check for immune responses to the drug through antibody testing, ensuring comprehensive safety and effectiveness evaluations during the study period.

CONDITIONS

Brief Title

A Comparative Study to Investigate the Difference in Blood Levels of Two Different Formulations of GSK5784283

Who Can Participate

Age: 18Years - 60Years

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Healthy adults as confirmed by medical evaluation including history, physical exam, lab tests, and ECG
Body weight at least 50 kg (110 lbs) and BMI between 19 and 30 kg/m²
Females must be of non-childbearing potential as defined in the protocol
Able to give signed informed consent and follow study requirements

You will not qualify if you...

Allergy or intolerance to biologic therapies or ingredients used in subcutaneous products
Significant medical conditions that affect drug processing or pose study risks
Abnormal findings in exams or labs that may risk safety or affect study results
Live vaccines within 1 month before screening or planned during the study
Biologic treatments within 3 months or 5 half-lives before study dosing
Current smokers or former smokers with over 10 pack-years history, or users of vaping products
Excessive alcohol use beyond protocol limits
Sensitivity to study treatments or components contraindicating participation
QTc interval over 450 milliseconds on ECG

Research Team

US GSK Clinical Trials Call Center

EU GSK Clinical Trials Call Center

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