Actively Recruiting
Compare the Efficacy and Outcome Between Fentanyl and Morphine as Analgo-sedation in Mechanically Ventilated Patients
Led by Universiti Sains Malaysia · Updated on 2025-10-06
116
Participants Needed
1
Research Sites
76 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary aim of this clinical trial is to compare the effectiveness of fentanyl vs morphine as analgosedation in mechanically ventilated adult patients in the ICU. This study also aims to compare the outcomes of patients between the two groups. The main questions it aims to answer are : 1. Does propofol and fentanyl infusion as analgo-sedation achieve targeted sedation score at 12 and 24 hours compared to propofol and morphine infusion in mechanically ventilated adult patients in the intensive care unit (ICU)? 2. Is there a difference between the proportion of patients requiring rescue sedation dose between the fentanyl and morphine groups?
CONDITIONS
Official Title
Compare the Efficacy and Outcome Between Fentanyl and Morphine as Analgo-sedation in Mechanically Ventilated Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age >18 years old
- Patients expected by the ICU team to require invasive mechanical ventilation in ICU for more than 24 hours
- Patients who were ventilated and sedated for no more than 12 hours before ICU admission
- ICU team decides to initiate continuous infusion of sedation
You will not qualify if you...
- Patients with chronic use of narcotics
- Patients with chronic liver failure or end-stage renal failure
- Patients with severe chronic neurocognitive dysfunction
- Patients with drug overdose
- Patients allergic to morphine or fentanyl
- Patients receiving neuromuscular blockers
- Pregnant patients
- Patients diagnosed with severe traumatic brain injury
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hospital Universiti Sains Malaysia
Kota Bharu, Kelantan, Malaysia, 16150
Actively Recruiting
Research Team
M
Mohd Zulfakar Mazlan Dr, MBBS
CONTACT
S
Saravana Raj Joseph, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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