A Study Comparing Fentanyl and Morphine for Sedation in Adults on Mechanical Ventilation in the ICU

What this Trial Is About

Researchers are comparing the effectiveness of fentanyl versus morphine as analgosedation in adult patients who are mechanically ventilated in the intensive care unit ICU. The study aims to determine which sedation method better achieves targeted sedation scores at 12 and 24 hours and to compare the need for rescue sedation doses between the two groups. Additional outcomes include duration of mechanical ventilation, length of ICU stay, and 14-day mortality rate. Participants will be randomly assigned to receive either intravenous fentanyl infusion at a dose of 0.5 to 1 mcgkghr or intravenous morphine infusion at 0.05 to 0.1 mgkghr for sedation. The study drugs will be started according to group assignment, and sedation will be continuously infused while patients remain mechanically ventilated in the ICU. During the study, researchers will monitor sedation scores using the Richmond Agitation-Sedation Scale RASS at 12 and 24 hours after drug initiation. They will also record the need for rescue sedation doses within 24 hours. Secondary outcomes such as mechanical ventilation duration and ICU length of stay will be followed for up to 90 days, and mortality will be assessed at 14 days. The total participation duration will vary based on patient condition and ICU stay length.

Compare the Efficacy and Outcome Between Fentanyl and Morphine as Analgo-sedation in Mechanically Ventilated Patients