Actively Recruiting

Phase Not Applicable
Age: 18Years - 80Years
All Genders
NCT07561333

Comparing ACB+IPACK and ACB+BiFeS Block Combinations for Analgesia in Total Knee Arthroplasty

Led by Hitit University · Updated on 2026-05-01

78

Participants Needed

1

Research Sites

56 weeks

Total Duration

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AI-Summary

What this Trial Is About

Total knee arthroplasty (TKA) is associated with severe postoperative pain that delays mobilization, prolongs hospital stay, and reduces patient satisfaction. Regional analgesia techniques have gained prominence due to their opioid-sparing effects and favorable complication profiles compared to general anesthesia. While adductor canal block (ACB) effectively manages anterior knee pain with preserved motor function, posterior knee pain remains a challenge. IPACK (Infiltration between the Popliteal Artery and Capsule of the Knee) and the Biceps Femoris Short Head (BiFeS) block are techniques targeting posterior capsule innervation without causing motor block.This prospective study aims to compare the postoperative analgesic efficacy of ultrasound-guided ACB+IPACK versus ACB+BiFeS block combinations in patients undergoing TKA under spinal anesthesia. Patients (ASA I-III, age 18-80, BMI ≤35) will be randomized into two groups (n=39 each). Primary outcomes include NRS pain scores at rest and on movement, and opioid consumption at 0, 1, 3, 6, 12, 18, and 24 hours postoperatively. Secondary outcomes include time to first mobilization, motor block incidence, quadriceps muscle strength assessment, PONV, and quality of recovery (QoR-15).

CONDITIONS

Official Title

Comparing ACB+IPACK and ACB+BiFeS Block Combinations for Analgesia in Total Knee Arthroplasty

Who Can Participate

Age: 18Years - 80Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Scheduled for primary total knee arthroplasty surgery
  • ASA physical status classification I-III
  • Hemodynamically stable
  • Age 18 years or older and 80 years or younger
  • Body mass index (BMI) 35 kg/m2 or less
  • Signed written informed consent form
Not Eligible

You will not qualify if you...

  • Revision total knee arthroplasty surgery
  • Simultaneous bilateral total knee arthroplasty
  • Body mass index (BMI) over 40 kg/m2
  • ASA physical status classification 4 or 5
  • Unable to perform numeric pain rating scale (NRS) scoring
  • Known allergy to local anesthetics
  • Pregnancy or breastfeeding
  • Age younger than 18 years or older than 80 years
  • Uncontrolled anxiety disorder
  • Alcohol or drug dependency
  • Neuromuscular or peripheral nerve disease
  • High-dose opioid use within 3 days before surgery
  • Widespread chronic pain syndrome
  • Diabetes mellitus
  • Hepatic or renal insufficiency
  • Coagulation disorders
  • Current use of anticoagulant medications
  • Infection at the nerve block needle insertion site
  • Refusal to participate in the study

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 1 location

1

Hitit University

Çorum, Centre, Turkey (Türkiye), 19100

Actively Recruiting

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Research Team

M

Merve YAGIZ BALDIRAN, MD

CONTACT

A

Arzu AKDAGLI EKICI, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

2

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