Actively Recruiting

Phase Not Applicable
Age: 18Years - 80Years
All Genders
ID07561333

Comparison of Analgesic Efficacy of IPACK Versus Biceps Femoris Short Head Block Combined With Adductor Canal Block in Total Knee Arthroplasty

Led by Hitit University · Updated on 2026-05-01

78

Participants Needed

1

Research Sites

4 weeks

Total Duration

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AI-Summary

What this Trial Is About

Total knee arthroplasty (TKA) is performed for severe knee conditions but often causes intense pain after surgery, which can delay movement, extend hospital stays, and lower patient satisfaction. Researchers are studying two combinations of regional nerve blocks to manage this pain better while preserving muscle strength: the adductor canal block (ACB) with IPACK block and ACB with Biceps Femoris Short Head (BiFeS) block. This study is prospective, randomized, and aims to compare the effectiveness of these two approaches in controlling postoperative pain under spinal anesthesia. Participants will be divided into two groups receiving ultrasound-guided nerve blocks. One group will get ACB combined with IPACK block, while the other will receive ACB combined with BiFeS block, both using specific doses of bupivacaine. All patients will also receive spinal anesthesia during surgery. The study includes standardized postoperative pain management with paracetamol and patient-controlled tramadol, with rescue fentanyl available as needed. Pain scores and opioid use will be tracked at multiple time points during the first 24 hours after surgery. Participants will undergo regular assessments including pain ratings at rest and movement, muscle strength tests, and monitoring of side effects like nausea and vomiting. Researchers will also record recovery quality, vital signs, time to first mobility, and bowel function. The primary outcome is total opioid consumption in the first 24 hours, with additional measures such as time to first mobilization and motor block incidence. The study will last through the immediate postoperative period with careful monitoring and safety criteria to stop participation if severe pain occurs.

CONDITIONS

Brief Title

Comparing ACB+IPACK and ACB+BiFeS Block Combinations for Analgesia in Total Knee Arthroplasty

Who Can Participate

Age: 18Years - 80Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Scheduled for primary total knee arthroplasty surgery
  • ASA physical status classification I-III
  • Hemodynamically stable
  • Age 18 years or older and 80 years or younger
  • Body mass index (BMI) of 35 kg/m2 or less
  • Signed written informed consent form
Not Eligible

You will not qualify if you...

  • Revision total knee arthroplasty surgery
  • Simultaneous bilateral total knee arthroplasty
  • Body mass index (BMI) greater than 40 kg/m2
  • ASA physical status classification 4 or 5
  • Inability to perform numeric rating scale (NRS) pain scoring
  • Known allergy to local anesthetics
  • Pregnancy or breastfeeding
  • Age younger than 18 or older than 80 years
  • Uncontrolled anxiety disorder
  • Alcohol or drug dependency
  • Neuromuscular disease or peripheral nerve disease
  • High-dose opioid use within 3 days prior to surgery
  • Widespread chronic pain syndrome
  • Diabetes mellitus
  • Hepatic or renal insufficiency
  • Coagulation disorders
  • Current use of anticoagulant medications
  • Infection at the peripheral nerve block needle insertion site
  • Refusal to participate in the study

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - Surgery day and immediate postoperative period

Participants receive total knee arthroplasty surgery under spinal anesthesia with either ultrasound-guided adductor canal block combined with IPACK block or adductor canal block combined with Biceps Femoris Short Head block for postoperative analgesia.

1 surgical and block application visit (in-person)

Post-operative Follow-up

Duration - 24 hours post surgery

Participants are monitored for pain, opioid consumption, quadriceps muscle strength, and recovery outcomes during the first 24 hours after surgery.

Multiple assessments at postoperative hours 0, 1, 2, 3, 6, 12, 18, and 24

Trial Site Locations

Total: 1 location

1

Hitit University

Çorum, Centre, Turkey (Türkiye), 19100

Actively Recruiting

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Research Team

M

Merve YAGIZ BALDIRAN, MD

A

Arzu AKDAGLI EKICI, MD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

2

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