Actively Recruiting
Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
Led by University of Michigan · Updated on 2026-04-17
900
Participants Needed
8
Research Sites
229 weeks
Total Duration
On this page
Sponsors
U
University of Michigan
Lead Sponsor
P
Patient-Centered Outcomes Research Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
This trial is being completed to compare two commonly used options to treat pain after surgery. Participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible to enroll. Eligible participants will be randomized to 1 of 2 groups of medications (Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) plus acetaminophen or low dose opioids plus acetaminophen). It is anticipated that the NSAID group will have superior clinical outcomes and fewer side effects when compared to the opioid group.
CONDITIONS
Official Title
Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- No significant use of opioid or NSAID prescriptions in the past 30 days
- No over-the-counter NSAID use on more than 7 of the past 30 days
- Scheduled for one of these low-risk surgeries: laparoscopic gallbladder removal, inguinal hernia repair, or breast lumpectomy
You will not qualify if you...
- Planned additional surgery within 6 months or life expectancy less than 6 months
- Known contraindications to NSAIDs if assigned to NSAID group
- Known contraindications to opioids if assigned to opioid group
- Known contraindications to acetaminophen
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
2
Henry Ford Health System
Detroit, Michigan, United States, 48202
Actively Recruiting
3
Washington University in Saint Louis
St Louis, Missouri, United States, 63130
Actively Recruiting
4
Cooper University Health Care
Camden, New Jersey, United States, 08103
Actively Recruiting
5
University of North Carolina Hospitals
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
6
Temple University - Temple Health
Philadelphia, Pennsylvania, United States, 19140
Actively Recruiting
7
Women's College Hospital
Toronto, Ontario, Canada, M5S 1B2
Actively Recruiting
8
Unity Health Toronto
Toronto, Ontario, Canada
Actively Recruiting
Research Team
S
Sarah Clark, BA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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