Actively Recruiting
Comparing Antibiotic Treatment Strategies for Children With Pneumonia in Outpatient Settings: (STAMPP)
Led by Ann & Robert H Lurie Children's Hospital of Chicago · Updated on 2026-01-27
2000
Participants Needed
4
Research Sites
200 weeks
Total Duration
On this page
Sponsors
A
Ann & Robert H Lurie Children's Hospital of Chicago
Lead Sponsor
P
Patient-Centered Outcomes Research Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to determine if a "watch and wait" antibiotic strategy, called Safety Net Antibiotic Prescribing (SNAP), can safely reduce unnecessary antibiotic use while ensuring that children diagnosed with community-acquired pneumonia get better from their illness. The main aims of this study are: * To compare the effectiveness of SNAP versus immediate antibiotic prescribing in children with mild community-acquired pneumonia (CAP) * To identify which patient groups benefit most from the SNAP strategy * To identify factors that shape implementation of each prescribing strategy. Researchers will compare the SNAP strategy (where parents or guardians are instructed to give antibiotics only if their child is not improving after 72 hours, or sooner if they are worsening) to the immediate antibiotic prescribing strategy (where parents or guardians are instructed to give the antibiotics right after their healthcare visit) to see if one strategy is more effective than the other. Participants will be randomly assigned to either the immediate antibiotic group or the SNAP group at enrollment. Participation lasts 14 days with follow-up surveys at 4, 7, and 14 days after enrollment.
CONDITIONS
Official Title
Comparing Antibiotic Treatment Strategies for Children With Pneumonia in Outpatient Settings: (STAMPP)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signs and symptoms of lower respiratory tract infection
- Diagnosis of community-acquired pneumonia (CAP) by a clinician
- Treating clinician intends to prescribe antibiotics for CAP
- Child is well enough to be managed as an outpatient
- Parent or guardian of enrolled child, or clinician or practice staff involved in prescribing decisions or implementation
You will not qualify if you...
- Hospitalization within the previous 7 days
- Oxygen saturation below 90%, if measured
- Incomplete immunization status (missing at least 3 pneumococcal vaccine doses)
- Chronic medical conditions increasing bacterial CAP risk (e.g., chronic lung disease, cystic fibrosis, sickle cell disease)
- Substantially immunocompromised status (e.g., immunodeficiency, active cancer treatment, organ transplant with immunosuppressive agents)
- Receipt of oral or parenteral antibiotics within the previous 7 days
- Diagnosis of complicated pneumonia (e.g., empyema, lung abscess)
- Known bacterial infection requiring immediate antibiotics
- Pneumonia diagnosis within the previous 6 months
- Prior enrollment in this trial
- Inability of parent or guardian to speak English or Spanish for aims 1 and 2
- Inability of parent or guardian to speak English for aim 3
AI-Screening
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Trial Site Locations
Total: 4 locations
1
Children's Healthcare of Atlanta
Atlanta, Georgia, United States, 30329
Actively Recruiting
2
Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, United States, 60611
Actively Recruiting
3
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
4
Primary Children's Hospital
Salt Lake City, Utah, United States, 84108
Actively Recruiting
Research Team
T
Todd Florin, MD, MSCE
CONTACT
J
Julia Szymczak, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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