Actively Recruiting
Comparing Anticoagulation Strategies Using UFH, Argatroban and LMWH for ECMO Support
Led by Medical University of Vienna · Updated on 2024-10-29
90
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A three-arm randomized controlled non-inferiority pilot study comparing anticoagulation strategies using unfractionated heparin, argatroban and enoxaparin for extracorporeal membrane oxygenation support conducted as an investigator-initiated, prospective, parallel group, open-label, active comparator controlled, single center, phase IV study to evaluate the non-inferiority of enoxaparin or argatroban for anticoagulation during ECMO therapy in comparison to the current standard, unfractionated heparin, as measured by the incidence of thromboembolic events during the duration of ECMO therapy
CONDITIONS
Official Title
Comparing Anticoagulation Strategies Using UFH, Argatroban and LMWH for ECMO Support
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Require ECMO support or have started ECMO therapy within the last 12 hours
You will not qualify if you...
- Contraindications to anticoagulation or to any of the three study drugs
- Pregnancy
- Clinically relevant pre-existing coagulopathy
- Inability to start study protocol within 12 hours after ECMO cannulation
- Ongoing therapeutic systemic anticoagulation before ECMO or indication for it
- Total ECMO support expected to last less than 24 hours
- ECMO started during cardiopulmonary resuscitation (eCPR)
- Passive decarboxylation without active pumping system
- Weaned off ECMO support within the last 30 days
- Central ECMO cannulation and/or after cardiopulmonary bypass
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Medical University of Vienna
Vienna, State of Vienna, Austria, 1090
Actively Recruiting
Research Team
V
Vincenz Scharner, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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