Randomized Trial Comparing Different Corticosteroid Doses in Local Pain Relief for Total Knee Replacement Surgery

What this Trial Is About

Researchers are evaluating the effectiveness and safety of different doses of glucocorticoids added to local infiltration analgesia LIA during total knee arthroplasty TKA. This prospective single-center randomized controlled trial aims to find the best dose to manage pain after TKA, improve recovery, and enhance patients quality of life following surgery. Participants will be randomly assigned to one of four groups high-dose LIA with 3 vials of Diprospan, medium-dose with 2 vials, low-dose with 1 vial, or a control group receiving LIA without Diprospan. Diprospan contains betamethasone and betamethasone dipropionate, and the study compares these varying doses to assess their impact on pain control. During the study, pain levels will be measured using the Visual Analog Scale VAS at baseline and multiple time points up to 6 weeks after surgery. Additional assessments include the Western Ontario and McMaster Universities Osteoarthritis Index WOMAC, range of motion, and various blood tests to monitor inflammation and organ function. Researchers will also track postoperative analgesic use and the incidence of complications up to 6 months. The total study duration includes follow-up visits at 3 and 6 weeks postoperatively.

Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty