Actively Recruiting
Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty
Led by First Affiliated Hospital of Fujian Medical University · Updated on 2026-01-13
120
Participants Needed
1
Research Sites
143 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to compare the efficacy of different doses of glucocorticoids in local infiltration analgesia (LIA) during total knee arthroplasty (TKA) through a prospective single-center randomized controlled trial, and to explore the safety and feasibility of high-dose glucocorticoids. Through this research, the investigators hope to provide an optimized solution for post-TKA pain management, improve patients' postoperative recovery and quality of life, and offer scientific evidence for pain management following TKA.
CONDITIONS
Official Title
Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female participants aged 18 years or older
- Undergoing primary unilateral total knee arthroplasty for unilateral knee osteoarthritis at the study hospital
- Preoperative American Society of Anesthesiologists (ASA) physical status classification of 1-3
- Able to provide and sign written informed consent
You will not qualify if you...
- Previous surgery or infection in the knee to be operated on
- Non-osteoarthritis conditions such as rheumatoid arthritis, traumatic arthritis, septic arthritis, or hemophilic arthritis
- Severe osteoarthritis with flexion contracture greater than 30 degrees or varus/valgus deformity greater than 30 degrees
- Allergy to study-related drugs
- Neuromuscular dysfunction in the same limb as the operative knee
- Dependence on anesthetic drugs, defined as weekly opioid use over 100 mg morphine equivalents or local anesthetics for more than 3 months preoperatively
- Poor systemic health including HbA1c level over 12%, blood pressure over 170/110 mmHg, recent heart attack, stroke, transient ischemic attack, acute heart failure, or coronary events within 6 months
- Dialysis or kidney transplant
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Fujian Medical University
Fuzhou, Fujian, China, 350004
Actively Recruiting
Research Team
C
Chaofan Zhang, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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