Actively Recruiting
Comparing Diosmin-Hesperidin and Loratadine to Prevent Bone Pain From G-CSF in Patients With Blood Cancers
Led by Alexandria University · Updated on 2025-12-29
88
Participants Needed
1
Research Sites
69 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a comparative interventional study to determine the best way to prevent G-CSF induced bone pain in patients with hematological malignancies (blood cancers). G-CSF (Granulocyte Colony-Stimulating Factor) is a drug commonly used in these patients to boost white blood cell production, but it frequently causes severe bone pain. The study is comparing two oral medications for their effectiveness as a preventive treatment: * Diosmin-Hesperidin (a flavonoid supplement). * Loratadine (a common anti-allergy medication). The core question the study is trying to answer is: * Is diosmin-hesperidin effective in preventing G-CSF-induced bone pain compared to loratadine? * Does the combination of diosmin-hesperidin and loratadine offer better pain prevention than either drug alone?
CONDITIONS
Official Title
Comparing Diosmin-Hesperidin and Loratadine to Prevent Bone Pain From G-CSF in Patients With Blood Cancers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 to 65 years old
- Receiving G-CSF treatment for leukemia, lymphoma, or neutropenia prevention after autologous hematopoietic cell transplant
- Patients may have bone pain associated with G-CSF administration or not
- Willing to provide informed consent to participate in the study
You will not qualify if you...
- Patients with solid tumors
- Pregnant or breastfeeding women
- Known allergies or hypersensitivity to loratadine, diosmin-hesperidin, or filgrastim
- Patients with pre-existing bone disorders or receiving bone modifying agents
- Chronic use of antihistamines, diosmin-hesperidin, NSAIDs, corticosteroids, or immunosuppressants
- Receiving medications with major interactions with loratadine, diosmin-hesperidin, or filgrastim
- Unable to understand or provide informed consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
Alexandria University Hospitals
Alexandria, Egypt, 21532
Actively Recruiting
Research Team
M
Mayssaa Mohamed Elsayed, M.S. Candidate
CONTACT
N
Noha AlaaEldine Hamdy, Assistant professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
4
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