Actively Recruiting
Comparing the Efficacy of Different Durations of Maribavir Treatment Regimens in Allo-HSCT
Led by Ruijin Hospital · Updated on 2026-04-06
218
Participants Needed
1
Research Sites
148 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To comparing the efficacy of different durations of Maribavir treatment regimens in patients suffering from refractory CMV infection after allo-HSCT.
CONDITIONS
Official Title
Comparing the Efficacy of Different Durations of Maribavir Treatment Regimens in Allo-HSCT
Who Can Participate
Eligibility Criteria
You may qualify if you...
- First allogeneic hematopoietic stem cell transplantation
- Age 18 years or older
- Confirmed refractory CMV infection, defined as persistent or increasing CMV levels despite at least 2 weeks of antiviral therapy, drug-resistant CMV infection with specific gene mutations, or intolerance to antiviral therapy due to severe side effects
- Willingness to provide written informed consent and participate in the study
You will not qualify if you...
- Known allergy or hypersensitivity to any component of Maribavir
- Active hepatitis B infection with HBV DNA level 1 × 10³ IU/mL or higher
- Confirmed HIV infection
- Severe impairment of major organs such as respiratory failure, heart failure, decompensated liver insufficiency, or kidney failure
- CMV infection affecting the central nervous system
- History of substance use disorder or chronic alcoholism that could affect study results
- Psychiatric disorder or cognitive impairment preventing informed consent
- Any other condition considered by the investigator to make the participant unsuitable for the trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Ruijin Hospital, Shanghai JiaoTong University School of Medicine
Shanghai, China
Actively Recruiting
Research Team
X
Xiaoxia Hu
CONTACT
L
Luxiang Wang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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