Actively Recruiting
Comparing the Efficacy of Lyophilized Self Growth Factor Versus PRP Injection for Knee OA
Led by Tri-Service General Hospital · Updated on 2025-09-10
90
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Knee osteoarthritis(OA) is a common degenerative joint disease that often leads to knee pain, stiffness, and a decline in quality of life among middle-aged and elderly individuals. Platelet-rich plasma (PRP) is a regenerative treatment method that involves drawing a small amount of the patient's own blood and using centrifugation process to produce PRP. PRP, which is rich in growth factors and anti-inflammatory cytokines, facilitate the repair of damaged tissues and has been used in treating knee OA. Self-repair factor (SRF), an advanced form of PRP, is created using multi-step centrifugation and proprietary processes to increase platelet concentration. This enhancement may offer superior repair efficacy and faster recovery compared to traditional PRP. To explore this potential, we designed a randomized, double-blind, clinical trial to compare the effectiveness of SRF and PRP in treating degenerative knee osteoarthritis.
CONDITIONS
Official Title
Comparing the Efficacy of Lyophilized Self Growth Factor Versus PRP Injection for Knee OA
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female, aged over 20 and under 80
- Clear consciousness and able to communicate
- Unilateral or bilateral knee osteoarthritis with symptoms lasting more than 3 months
- X-ray shows mild to moderate knee osteoarthritis (Kellgren-Lawrence grades 1-3)
- Knee pain with a Visual Analogue Scale score greater than 4
You will not qualify if you...
- Severe knee osteoarthritis (Kellgren-Lawrence grade 4)
- Current systemic infection
- Received hyaluronic acid or corticosteroid knee injections within past 6 months
- Used NSAIDs or oral corticosteroids within 7 days before treatment
- Previous joint replacement surgery or major surgery on treated knee
- Severe knee deformity or instability
- History of cancer, rheumatoid arthritis, platelet disorders, thrombocytopenia, hypofibrinogenemia, infectious diseases, chronic liver disease, or poorly controlled heart disease or diabetes
- Currently on anticoagulant therapy
- Long-term or excessive aspirin or vitamin E use
- History of HIV/AIDS, syphilis, or other legally notifiable infectious diseases
- Pregnant or breastfeeding women, or those unable to use effective contraception
- Deemed unsuitable by the principal investigator
- Unable to sign informed consent form
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
No. 325, Sec. 2, Chenggong Rd., Neihu Dist.
Taipei, Taiwan, 114
Actively Recruiting
Research Team
Y
Yu Chi Su,, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
NA
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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