Comparing Fluid Responsiveness Assessment Methods in Patients With Impaired Consciousness: A Comprehensive Crossover Study Examination

What this Trial Is About

Researchers are investigating the effectiveness of various methods to assess fluid responsiveness in patients with hypotension and decreased levels of consciousness, a condition often seen in intensive care units. The study aims to determine the sensitivity and specificity of tests like inferior vena cava diameter measurements, passive leg raising (PLR) tests, and fluid challenges (FC) to better predict patient responses to infusion therapy. This research addresses the gap in data concerning patients with altered consciousness and aims to improve infusion therapy management in this vulnerable group. The study involves a sequence of assessments starting with measuring the diameter of the inferior vena cava, followed by central venous pressure evaluation. After a brief interval, the passive leg raising test is performed, then a 15-minute wait precedes the fluid challenge test. Following these assessments, participants receive a balanced crystalloid infusion of 1000 ml at a rate of 15 ml/kg/h, adjusted for any prior infusions during the fluid challenge. The study uses these methods to compare responses and evaluate fluid responsiveness. Participants will be monitored through various clinical measurements including blood pressures, central venous pressure, and cardiac output. Data collection includes detailed diagnostic test results such as true and false positives and negatives, with statistical analysis planned to evaluate diagnostic accuracy. The study follows participants through these assessments and infusion therapy to measure outcomes related to fluid responsiveness, with results assessed over an average of one year. Safety and adherence to protocols are monitored throughout the study period.

Comparing Fluid Responsiveness Assessment Methods in Patients With Impaired Consciousness