Actively Recruiting
Comparing Haloperidol to Olanzapine in the Treatment of Suspected Cannabinoid Hyperemesis in the Emergency Department
Led by Mercy Bon Secours Saint Vincent Medical Center · Updated on 2025-11-24
114
Participants Needed
1
Research Sites
51 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of the study is to identify which medication (haloperidol or olanzapine) is most effective in treating nausea and abdominal pain associated with cannabinoid hyperemesis using a 10-point visual analog scale with intervals of 0.5.
CONDITIONS
Official Title
Comparing Haloperidol to Olanzapine in the Treatment of Suspected Cannabinoid Hyperemesis in the Emergency Department
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Use cannabis by inhalation nearly every day for at least 6 months
- Have a previous diagnosis of cannabinoid hyperemesis, OR
- Have had 3 or more vomiting episodes in a cyclic pattern separated by over 1 month during the last 2 years, OR
- The doctor suspects cannabinoid hyperemesis as the main or equally likely diagnosis
You will not qualify if you...
- Younger than 18 years old
- Weigh less than 50 kg
- Are pregnant or breastfeeding
- Use benzodiazepines daily
- Have a prolonged QTc interval on ECG
- Have known allergy or intolerance to haloperidol or olanzapine
- Take drugs that cannot be combined with haloperidol or olanzapine
- Have Parkinson's Disease
- Are already taking haloperidol, olanzapine, or other antipsychotics
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mercy Saint Vincent Medical Center
Toledo, Ohio, United States, 43608
Actively Recruiting
Research Team
J
Joseph Jabour, DO FACEP
CONTACT
A
Amanda Gutek
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
2
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